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USP18 inhibits autophagy. 2 / 2

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"Thus, blocking Lys63 ubiquitination of selected target proteins by ISGylation may provide a general mechanism for type I IFN and ISG15 to modulate target activities.Our study demonstrates that USP18 positively regulates autophagy and EGFR degradation by promoting de-ISGylation of BECN1."

25906440

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reach

"USP18 mediates deISGylation of BECN1 to promote autophagy and EGFR degradation."

25906440

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IndraLab

Statements

USP18 inhibits autophagy. 2 / 2

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