IndraLab

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USP20 increases the amount of MCL1. 5 / 5
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"We found that USP20 but not its enzymatically inactive mutant USP20–C154S could up-regulate the protein level of MCL1 ( Fig. 2 a)."
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"Consistent with our above finding, when contrasted with full-length USP20, only the USP20 construct bearing the enzymatic domain, aa 145–689 but not aa 1–144 and 690–914, significantly increased the M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, knockdown of USP20 could reduce the level of MCL1 and render cells more sensitive to the BH3 mimetic compound, ABT-263."
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"Moreover, USP20 expression could also up-regulate the endogenous MCL1 protein level without influencing the MCL1 RNA expression level ( Fig. 1 c and d)."
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"Furthermore, knockdown of USP20 decreased MCL1 protein levels ( Fig. 1 e)."
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