IndraLab

Statements

PLAUR binds LDLR. 6 / 6
| 1 1 4
trips
"Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity."
11359936
reach
"We used hepatic overexpression of soluble full-length murine uPAR in Western-diet fed LDLR -/- mice acting as a decoy receptor for uPAR ligands and competing endogenous membrane bound uPAR."
26313756
sparser
"In addition, uPAR can interact with low-density lipoprotein receptor (LRP), and this uPAR/LRP interaction is associated with uPAR recycling [ xref ]."
36675310
sparser
"After uPA inhibition, uPA–PAI complexes facilitate the interaction between uPAR and low-density lipoprotein receptor, thereby stimulating endocytosis of uPA–PAI complexes and partial recycling of uPAR to the cell surface [ xref ]."
37884951
sparser
"We noted that maspin (a) colocalized with uPA and uPA receptor (uPAR), (b) enhanced the interaction between uPAR and low-density lipoprotein receptor related protein, and (c) induced rapid internalization of uPA and uPAR."
16618739
sparser
"LR11 colocalizes with uPAR on the cell surface and inhibits the LDL receptor-related protein (LRP)-mediated binding and internalization of uPAR."
14764453