IndraLab

Statements

Lactate inhibits DDX58. 8 / 8
| 5 2 1
sparser
"In order to unravel the underlying mechanism by which lactate inhibits RIG-I-MAVS induced RLR activation, we explored whether lactate impacts the mitochondria localization of MAVS by binding to its TM domain, ( xref )."
31155231
reach
"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS, which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling (329)."
31379819
eidos
"Mechanistically , HBV promotes HK activity and stimulates LDHA to produce lactate , which in turn interacts with MAVS and subsequently inhibits the RIG-I / MAVS interaction and MAVS aggregation and downstream signaling which would otherwise stimulate IFN production ( Fig. 7 ) ."
33397935
eidos
"Elevated lactate levels have been reported to inhibit RIG-I signaling , which could explain our observations ( Zhang et al. 2019 ) ."
| PMC
reach
"Elevated lactate levels have been reported to inhibit RIG-I signaling, which could explain our observations (Zhang, et al. 2019) ."
32634445
eidos
"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS , which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling ( 329 ) ."
31379819
eidos
"Elevated lactate levels have been reported to inhibit RIG-I signaling , which could explain our observations ( Zhang , et al. 2019 ) ."
32634445
eidos
"HBV promotes HK activity and lactate production that interacts with MAVS and subsequently inhibits the RIG-I / MAVS interaction and IFN-beta production ."
33397935