IndraLab

Statements

Lactate inhibits RIGI. 13 / 13
| 4 7 2
reach
"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS, which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling (329)."
31379819
reach
"The knockout of RIG-I weakened the regulatory effect of oxamate and lactate on IFNs production and lactate slightly inhibit the production of IFNs in RIG-I-KO cells, suggesting that lactate may inhibit IFNs by other pathways, however, it mainly via RIG-I signaling to manipulate SVA-induced innate immunity."
37126525
sparser
"In order to unravel the underlying mechanism by which lactate inhibits RIG-I-MAVS induced RLR activation, we explored whether lactate impacts the mitochondria localization of MAVS by binding to its TM domain, ( xref )."
31155231
sparser
"We found that lactate inhibits RIG-I, MDA5, and MAVS-induced IFN-β promoter activity ( Fig. 5 C)."
37586149
eidos
"Elevated lactate levels have been reported to inhibit RIG-I signaling , which could explain our observations ( Zhang , et al. 2019 ) ."
32634445
reach
"Glycolysis-induced lactate production inhibits retinoic acid-inducible gene 1 (RIG-I) ( Zhang et al., 2019 ) and mitochondrial anti-viral signaling (MAVS) protein ( Yasukawa et al., 2020 ), both requi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36309082
reach
"Elevated lactate levels have been reported to inhibit RIG-I signaling, which could explain our observations (Zhang, et al. 2019) ."
32634445
reach
"It has been reported that the glycolytic by-product lactate impedes retinoic acid-inducible gene I (RIG-I) like receptors (RLRs) mediated type-I IFNs production, impairing cancer immunosurveillance [71]."
36510194
eidos
"HBV promotes HK activity and lactate production that interacts with MAVS and subsequently inhibits the RIG-I / MAVS interaction and IFN-beta production ."
33397935
reach
"Interestingly, it was recently proposed that lactate produced during virus-induced aerobic glycolysis inhibits RIG-I signaling, thus suppressing RIG-I-mediated IFN synthesis and allowing viral replication [42]."
37939149
eidos
"Elevated lactate levels have been reported to inhibit RIG-I signaling , which could explain our observations ( Zhang et al. 2019 ) ."
| PMC
reach
"In addition, to inhibit RLR signaling, HBV promotes the activity of hexokinase (HK) and the production of lactate, which suppresses the interaction of RIG-I with MAVS and blocks IFN production (Zhou et al., 2021)."
36506030
eidos
"Mechanistically , HBV promotes HK activity and stimulates LDHA to produce lactate , which in turn interacts with MAVS and subsequently inhibits the RIG-I / MAVS interaction and MAVS aggregation and downstream signaling which would otherwise stimulate IFN production ( Fig. 7 ) ."
33397935