IndraLab

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"In addition, butyrate has been shown to inhibit the LPS-induced translocation of NF-κB p65 from the cytoplasm to the nucleus in THP-1 monocytes and in PBMCs, and NF-κB p65 has also been shown to be inhibited by butyrate in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis."
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"In conclusion, the present study demonstrated that EEN attenuated DSS- and TNBS induced colitis by inhibiting p65 activation via regulating the p38 and MSK1 pathway, thus suggesting that EEN is effective in the treatment of colitis."
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