IndraLab

Statements



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"Together, these results suggest that USP9X interacts with BRCA1.3.4 USP9X promotes HR repair partially through BRCA1."

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"HR assays showed that knockdown of USP9X significantly reduced HR efficiency, which was partially rescued by reintroduction of BRCA1 into USP9X-depleted cells."

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"Together, these data suggest that USP9X promotes HR repair of DSB partially through BRCA1.3.5 USP9X depletion increases the sensitivity of cancer cells to DNA-damaging agents."

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"Therefore, if USP9x increases MCL-1 expression [XREF_BIBR], then it could be suggested the USP9x indirectly promotes HR repair via MCL-1."