IndraLab

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USP9X decreases the amount of NFE2L2. 4 / 4
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"The protein levels of USP9X and Nrf2 were elevated by USP9X overexpression, yet diminished by USP9X silencing (Figure 2(F–H), p < 0.05)."
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"As shown in Fig. 7 C, AGEs increased the ubiquitination level of Nrf2, while overexpression of USP9X, instead of USP9X–C1556S, significantly reduced the ubiquitination level of Nrf2."
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"These data suggested that USP9X, relying on its deubiquitinase activity, reduced Nrf2 ubiquitination level to increase its protein expression, promoting the activation of Nrf2-ARE pathway.DN is one of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further researches revealed that USP9X could reduce the Nrf2 ubiquitination level in AGEs-treated GMCs, suggesting that USP9X, depending on its deubiquitinase activity, stabilized Nrf2 protein, and in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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