IndraLab

Statements

USP8 activates NFkappaB. 4 / 4
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"Therefore , by these findings , it can be concluded that USP8 , EGFR , PI3K , and P-Akt can activate NF-kappaB signaling where USP8 is a regulator of EGFR , PI3K , and P-Akt in PCa cell proliferation and survival ."
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"In contrast, the USP8-specific siRNA reduced EGFR and PI3K, suppressing the NF-kB signal."
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"Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway."
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"As USP8 silencing significantly inhibited the PCa cell growth, proliferation, and metastasis and induced apoptosis and suppressed NF-kB signal activation by decreasing EGFR and PI3K, the USP8-specific inhibitor might be a novel therapeutic target to suppress PCa cell growth, proliferation, and metastasis."
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