IndraLab

Statements

Lactate inhibits CASP1. 4 / 4
| 4
reach
"In macrophages and monocytes, increasing concentrations of lactate reduced TLR4 mediated induction of Il1B, Nlrp3, and Casp1; activation of NFkappaB; release of IL1beta; and cleavage of CASP1."
24657625
reach
"Moreover, Rhein remarkably decreases the levels of lactate dehydrogenase (LDH), GSDMD, NOD-like receptor protein 3 (NLRP3), TLR4, MyD88, NLRP3, IL-1β, IL-18, and IFN-γ, and increases the content of p10, p20, and p45 [79]."
36906602
reach
"XREF_BIBR, XREF_BIBR The reduction in TLR induced Pro Il1beta and inflammasome components Nlrp3 and Casp1 by lactate predicts that lactate would also reduce CASP1 activity, and IL1beta release, which is the case (XREF_FIG)."
24657625
reach
"In addition, LM-021 and LM-036 increased cell viability, reduced lactate dehydrogenase release, ameliorated cellular ROS production, decreased caspase-1, caspase-3 and caspase-6 activities, and promoted neurite outgrowth in MPP + -treated BE(2)-M17 cells."
39411284