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Lactate inhibits CASP1. 2 / 2

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"XREF_BIBR, XREF_BIBR The reduction in TLR induced Pro Il1beta and inflammasome components Nlrp3 and Casp1 by lactate predicts that lactate would also reduce CASP1 activity, and IL1beta release, which is the case (XREF_FIG)."

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"In macrophages and monocytes, increasing concentrations of lactate reduced TLR4 mediated induction of Il1B, Nlrp3, and Casp1; activation of NFkappaB; release of IL1beta; and cleavage of CASP1."

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Lactate inhibits CASP1. 2 / 2

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