IndraLab

Statements

USP1 activates BCL2. 4 / 4
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"In cultured CRC cells, knockdown of USP1 induced growth arrest at G 2 /M of cell cycle and reduced the expression of anti-apoptotic proteins Bcl-2 and Mcl-1."
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"The downregulation of USP1, USP8 and USP22 through their respective siRNA decreased Bcl-2 protein, as shown by western blot analysis."
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"Furthermore, while enforced expression of wild-type USP1 in HCT116 cells increased the mRNAs of Cyclin A1, D1, E1 as well as Bcl-2 and Mcl1, expression of inactive USP1 (USP1-C90S) did not affect the expression of these genes (Figure 3C)."
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"Since USP1 may potentially regulate Bcl-2, it would be interesting to investigate whether Bcl-2 plays a role in regulating apoptosis induced by the USP1 inhibitors."
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