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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP1 activates BCL2. 2 / 2

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"In cultured CRC cells, knockdown of USP1 induced growth arrest at G 2 /M of cell cycle and reduced the expression of anti-apoptotic proteins Bcl-2 and Mcl-1."

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"Furthermore, while enforced expression of wild-type USP1 in HCT116 cells increased the mRNAs of Cyclin A1, D1, E1 as well as Bcl-2 and Mcl1, expression of inactive USP1 (USP1-C90S) did not affect the expression of these genes (Figure 3C)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...