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CTNNB1 phosphorylates CTNNB1. 233 / 239
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"GSK-3β is a key component of β-catenin destruction complex that phosphorylates β-catenin and presents the protein for degradation."
20457486
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"Phosphorylation of beta-catenin by Gsk3beta targets beta-catenin to ubiquitination and proteasome degradation."
20140245
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"Without WNT ligands, beta-catenin is phosphorylated and degraded by a beta-catenin destruction complex, which includes AXIN, adenomatous polyposis coli (APC), and glycogen synthase kinase 3 (GSK-3)."
26562615
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"Under normal physiological conditions, cytoplasmic β-catenin is phosphorylated by the β-catenin destruction complex, which leads to its degradation in the proteasome."
34284111
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"In this study, we demonstrated that PDE1, particularly PDE1A, regulates beta-catenin and TCF signaling through PP2A B56gamma dependent regulation of GSK-3beta phosphorylation, beta-catenin phosphorylation, and beta-catenin protein degradation."
21078118
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"The Wnt and beta-catenin signaling pathway, also known as the canonical Wnt pathway, inhibits the phosphorylation and degradation of beta-catenin, which accumulates in the cytoplasm and translocates into the nucleus, where it binds to transcription factors (ternary complex factor and lymphoid enhancer factor 1, TCF and LEF1) and regulates the expression of a number of targeted genes."
28578392
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"Thus, it raises a question of how much it recapitulates the cytosolic environment of a regular cell.Furthermore, the biochemical model predicts that the β-catenin destruction complex would either stay[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28844868
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"Consistent with this, knocking down Akt1 completely reversed the FTZ-induced changes in the expression levels of Akt1, β-catenin and p-β-catenin, indicating that FTZ promotes phosphorylation of β-cate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35447198
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"This enzyme is an important member of the β-catenin destruction complex that phosphorylates β-catenin as a preceding step for its degradation, keeping the cytosolic concentrations of β-catenin low in the absence of Wnt ligands."
32674468
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"The activation of mutant p53 up-regulated the expression of p –β-catenin(S45) and p –β-catenin(Y333), resulting in unchanged expression patterns of β-catenin."
28111262
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"Active GSK-3β can prevent transcription of β-catenin target genes by stimulating the degradation of β-catenin protein and promoting the destruction of nuclear phosphorylated β-catenin [29, 30]."
38017514
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"Endogenous beta-catenin co-immunoprecipitated with endogenous activated FLT3, and recombinant activated FLT3 directly phosphorylated recombinant beta-catenin."
17851558
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"Figure 1A and B showed that an ox-LDL-stimulated β-catenin activation in NRK-52E cells, as revealed by up-regulation of phosphorylated (Ser675) β-catenin and down-regulation of phosphorylated (Ser33/37) β-catenin in a dose and time dependent manner.3.2 FXR activation improves ox-LDL-mediated tubulo-interstitial fibrosis."
38036169
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"Western blotting results revealed that Wnt2 overexpression suppressed inhibitory phosphorylation of β-catenin and increased total β-catenin level (Figure 7F)."
34853732
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"In the absence of WNT signaling, the beta-catenin destruction complex phosphorylates beta-catenin, leading to subsequent proteasomal degradation of the protein."
33425886
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"GSK3β-mediated β-catenin phosphorylation and the interaction between GSK3β and β-catenin supported by AXIN1 and APC can regulate the ubiquitination and/or stabilization of β-catenin, leading to its nuclear translocation, where it activates transcription (14)."
36104259
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"In the absence of Wnt ligands, the intracellular β-catenin destruction complex (mainly composed of APC, Axin1/2, GSK3β and CK1α) phosphorylates β-catenin."
38254219
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"Indeed, application of the TNF-α neutralizing antibody markedly block the stabilization of total β-catenin and non-phosphorylated (active) β-catenin in hypertonic culture (Fig.  xref F)."
38115136
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"In the absence of Wnt ligand, a beta-catenin destruction complex, composed of Axin, glycogen synthase kinase 3 (GSK3), casein kinase I alpha (CKIalpha), and the tumor suppressor adenomatous polyposis coli (APC), promotes phosphorylation of beta-catenin, targeting it for ubiquitin mediated proteasomal degradation."
22304967
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"Axin (Axil and conductin) binds to form a complex with APC, beta-catenin, and GSK3beta to promote beta-catenin phosphorylation and subsequent binding with slim (beta-TrCP) which mediates its ubiquitination and degradation in the proteasome [XREF_BIBR, XREF_BIBR]."
14672538
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"This process is initiated by the β-catenin destruction complex, a multiprotein complex composed of the scaffold proteins adenomatous polyposis coli (APC) and Axin1 [109–112] the protein kinases casein kinase 1 (CK1) and glycogen synthase kinase-3 (GSK3), which phosphorylate β-catenin on key serines/threonines [113–115]."
34871368
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"Furthermore, the phosphorylation of Src and β-catenin and the typical β-catenin downstream proteins MMP-7 and CD44 both decreased, but E-cadherin was increased in the orthotopic 4T1-luci-SHC4-mut1 tum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38052369
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"Signaling by Wnt ligands upon binding to transmembrane Frizzled (Fz) receptor and its co-receptors, LRP5/6 leads to the transduction of signals and accumulation of β-catenin in the cytoplasm by preventing GSK-3β-mediated phosphorylation and proteosomal degradation of β-catenin."
32132640
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"The beta-catenin destruction complex (βCdC) consisting of APC, axin, GSK3β, and CK1 phosphorylates β-catenin with the help of GSK3β."
39056802
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"APC forms together with Axin the core of the so-called beta-catenin destruction complex [ xref ], which phosphorylates beta-catenin, targeting it for ubiquitination and consequent proteasomal degradation ( xref )."
33348689
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"Additionally, Gtpbp2 −/− CD133 + CD44 − cells and Gtpbp2 +/+ CD133 + CD44 − cells expressed comparable total β-catenin and phosphorylated β-catenin, respectively ( xref )."
38468952
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"These activities are may lead to the phosphorylation of beta-catenin and target the phospho beta-catenin to proteosomal degradation, which essentially suppressed the Wnt and beta-catenin signaling pathway and expression of its target gene, cyclin D1."
29433490
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"In the absence of Wnt ligand, β -catenin may be phosphorylated by the β -catenin destruction complex composed of Axin, glycogen synthase kinase 3 β (GSK3 β ), casein kinase 1 α (CK1 α ), and adenomatous polyposis coli (APC) and subsequently degraded by the E3 ligase β -TrCP [ xref ]."
36694209
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"The knockdown of p66Shc inhibited both beta-catenin dephosphorylation that is stimulated by Wnt3a as well as beta-catenin dependent transcription."
25890053
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"When Wnt signaling is turned off, the tumor suppressor adenomatous polyposis coli (APC), Axin, and beta-catenin form protein complexes in the cytoplasm, leading to the phosphorylation of beta-catenin by CKI and GSK3beta, and its degradation by the 26S proteasome."
24388106
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"When cells were incubated in a TGF-β1 medium, the β-catenin phosphorylation site at the residue S37(p-S37 β-catenin) was shown to be restricted in the cytoplasmic lysates (P < 0.05); thus, there was an increase in nuclear β-catenin (P < 0.05) (Figure 6b)."
38584843
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"Axin is a scaffolding protein that embraces the GSK-3β and β-catenin proteins, which leads to β-catenin phosphorylation and degradation [5,6] ."
15878526
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"Thus, the multiprotein β-catenin “destruction complex” is inactivated to prevent β-catenin phosphorylation and its proteasomal degradation."
31500806
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"Mutations in exon 3 of the CTNNB1 gene that prevent phosphorylation and degradation of beta-catenin, a component of the adherens junction and a mediator of Wnt signalling pathway have been identified in adamantinomatous craniopharyngiomas and are possibly implicated in their pathogenesis."
29623208
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"In absence of Wnt ligands, the beta-Catenin destruction complex, comprising of APC, Axin and GSK3beta, phosphorylates beta-Catenin to initiate ubiquitin dependent degradation [XREF_BIBR, XREF_BIBR]."
33292279
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"CHIR99021 regulates the accumulation of β-catenin and phosphorylated β-catenin (p-β-catenin) [ 27 ], facilitates β-catenin to transport into the nucleus and inhibits cell differentiation [ 13 ]."
33049572
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"Dephosphorylated axin may have a lower affinity for beta-catenin, preventing beta-catenin degradation and hence increasing signaling by beta-catenin."
10712915
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"GSK3 beta is a negative regulator of the Wnt / beta-catenin signaling pathway as it forms a complex with other proteins and phosphorylates beta-catenin leading to degradation of the molecule [XREF_BIBR]."
26937223
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"In the absence of Wnt ligands, β-catenin phosphorylation, ubiquitination, and proteasome degradation, mediated by a β-catenin destruction complex, leads to low cytoplasmic β-catenin levels (Liebner and Plate, 2010)."
35799511
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"Importantly, these enhancers potentiated unphosphorylated β-catenin ubiquitylation with chain lengths similar to that of doubly-phosphorylated WT β-catenin."
30926793
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"The results showed that wild-type Htt functions as a scaffold protein, promoting β-catenin phosphorylation by the β-catenin destruction complex [47]."
37780577
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"It is well known that serine-phosphorylation of β-Catenin by the Axin-glycogen synthase kinase (GSK)-3β complex targets β-Catenin for degradation by the ubiquitination–proteosome pathway [7–10] , and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16996060
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"As the destruction complex of β-catenin induces the phosphorylation of β-catenin, β-TrCP may detect increased levels of phosphorylated β-catenin."
37917550
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"In the absence of Wnt ligand binding, the β-catenin destruction complex, composed of the scaffold proteins Adenomatosis Polyposis Coli and Axin (Axn), together with the protein kinases Casein-kinase 1α and Glycogen Synthase Kinase 3, phosphorylates the transcriptional cofactor β-catenin (Armadillo/Arm in Drosophila), leading to its degradation in the cytoplasm."
38968125
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"Phosphorylation of beta-catenin by active GSK3beta targets beta-catenin for ubiquitin mediated proteasomal degradation and maintains a low level of cytoplasmic beta-catenin."
18606491
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"Mutations in exon 3 of CTNNB1 at or around these positions cause decreased phosphorylation, ubiquitination, and proteolysis of β-catenin, which in turn leads to excessive Wnt signaling and activation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36150916
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"GSK3β is a critical regulator of β-catenin destabilization, which promotes the phosphorylation and ubiquitination of β-catenin, leading to β-catenin proteasomal degradation [44]."
33893396
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"ABC, alone and as part of ABC/DTG/3TC, increased osteoblastic beta-catenin activity as indicated by increased TOPFlash activity, hypo-phosphorylated (active) beta-catenin staining, and beta-catenin targeted gene expression."
38590756
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"This further supported the notion that the alterations caused by MIR3607 were mediated by the overactivation of β-catenin signaling.A major repressor of Wnt/β-catenin signaling is APC, a key component of a protein complex that phosphorylates β-catenin, driving it for proteasome degradation."
35020425
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"Imatinib, a Bcr-Abl antagonist, impairs the beta-catenin and TCF-related transcription causing a rapid cytosolic retention of Y unphosphorylated beta-catenin, which presents an increased binding affinity for the Axin and GSK3beta complex."
17318191
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"In the absence of Wnt ligand binding, the β-catenin destruction complex, composed of the scaffold proteins Adenomatosis Polyposis Coli and Axin (Axn), together with the protein kinases Casein-kinase 1α and Glycogen Synthase Kinase 3, phosphorylates the transcriptional cofactor β-catenin (Armadillo/Arm in Drosophila), leading to its degradation in the cytoplasm."
38968125
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"The expression of p53, β-catenin p -β-catenin(Y333/S45) after overexpressing or silencing in U87 and U251 cells had been tested."
28111262
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"The Wnt and beta-catenin signaling pathway inhibits phosphorylation of beta-catenin, thus resulting in its stabilization, cytoplasmic accumulation and subsequent nuclear translocation."
29568900
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"In the absence of wnt, beta-catenin is phosphorylated by the beta-catenin destruction complex and targeted for proteasomal degradation."
25371494
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"Blotting was performed to assess total β-catenin (1:10 000, Sigma-Aldrich), hypo-phosphorylated (active) β-catenin (1:1000, USBiological), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH, Sigma-Aldrich)."
38590756
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"In Wnt carcinogenesis, the cytoplasmic ' beta-catenin destroying complex ' fails to phosphorylate beta-catenin, thus, the complex does not mark it for ubiquitination."
26239915
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"In normal cells the degradation of β-catenin is regulated by Wnt signaling: β-catenin is constitutively phosphorylated by the β-catenin destruction complex, which marks β-catenin for ubiquitination followed by rapid proteasomal degradation ( xref ; xref ); Wnt signaling inactivates the β-catenin destruction complex, thereby inhibiting phosphorylation of β-catenin and consequently ubiquitination and degradation of the protein ( xref ; xref )."
26456834
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"In contrast, in the absence of Wnt ligand stimulation, β-catenin is phosphorylated and degraded by an intracellular β-catenin destruction complex, resulting in the inhibition of downstream gene expres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27692509
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"In the absence of Wnt signals, cytosolic β-catenin is phosphorylated by glycogen synthase kinase 3β (GSK-3β), which targets β-catenin for proteasome-mediated degradation."
15863038
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"The beta-catenin destruction unit consisting of proteins axin, glycogen synthase kinase (GSK) and an ancestral adenomatosis polyposis coli gene product in the cytoplasm is able to phosphorylate beta-catenin, thus, marking it for ubiquitination."
26239915
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"In pathological conditions, activation of Wnt signaling results in the disassembly of β-catenin destruction complex and prevention GSK3β-mediated phosphorylation of β-catenin."
32581789
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"Β-catenin is hypophosphorylated in the cytoplasm by the β-catenin destruction complex, following degradation via the ubiquitin–proteasomal pathway (Figure 1)."
40143326
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"However, neither stimulation with LIF or short-term treatment with a PI3K inhibitor, LY294002, showed any effect on the stability of β-catenin, although long-term treatment (around five days) of LY294[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17196549
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"Diversin recruits CKIepsilon to the beta-catenin degradation complex that consists of Axin and Conductin and GSK3beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin and Tcf signals."
12183362
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"Sustained activation of Wnt proteins causes the disassembly of the beta-catenin destruction complex, which can no longer phosphorylate beta-catenin for proteasome mediated degradation."
28219919
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"In the absence of Wnt ligands, β-catenin is constantly phosphorylated by a β-catenin destruction complex [comprised of adenomatous polyposis coli protein, axin, casein kinase 1α, and glycogen synthase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37926298
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"In short, when the Wnt/β-catenin signaling is not activated, the destruction complex that consists of casein kinase 1 (CK1ε), Axin, dishevelled (Dvl), adenomatous polyposis coli (APC), and glycogen synthase kinase-3β (GSK3β) sequesters β-catenin in the cytoplasm, phosphorylating β-catenin for degradation [ xref ]."
38539466
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"Obligate phosphorylation of β-catenin by CK1α and GSK3β target β-catenin for degradation ( xref ) by the proteasome ( xref )."
38585883
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"This dynamic change leads to a unique regulatory state of β-catenin, when β-catenin is phosphorylated, it can be ubiquitinated and further degraded by proteasomes [ xref ]."
39296108
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"In the absence of Wnt ligands, a complex between Axin, adenomatous polyposis coli (APC) tumor suppressor protein, casein kinase (CK) 2, glycogen synthase kinase (GSK) 3beta, and beta-catenin causes the phosphorylation of beta-catenin by GSK3beta and targets it for subsequent degradation by the proteasome XREF_BIBR, XREF_BIBR (XREF_FIG)."
28408959
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"We hypothesized that AMPK inhibits adipogenesis through Wnt and beta-catenin signaling pathway via phosphorylation of beta-catenin."
20361929
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"After induction, both NOD-MSCs and ICR-MSCs showed increased expression of β-catenin and phosphorylated β-catenin."
23229835
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"As a result, beta-catenin phosphorylation increases, then phosphorylated beta-catenin diffuses into the nucleus and binds to T-cell factor and lymphoid enhancer factor (TCF/LEF), which promotes the transcription."
25737167
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"Upon activation, they lead to a reduction in the so-called β-catenin destruction complex (APC/Axin/GSK3), which phosphorylates β-catenin and targets it for proteasomal degradation [ xref ]."
37762065
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"In the OFF state, or in the absence of extracellular Wnt ligands, cytoplasmic β-catenin is sequentially phosphorylated by the β-catenin destruction complex (DC) composed of casein kinase 1a (CK1), glycogen synthase kinase 3 (GSK-3), the scaffold protein axin, and the tumor suppressor adenomatous polyposis coli (APC)."
27226375
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"Within the context of canonical Wnt signaling, β-catenin is phosphorylated at particular sites by glycogen synthase kinase-3β (GSK-3β), which causes β-catenin to become ubiquitinated and degrade [51]."
39194730
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"If Wnt signaling is activated, beta-catenin degradation is inhibited due to the decreased ability of GSK3beta to phosphorylate beta-catenin and beta-catenin translocates into the nucleus to transactivate the Tcf/Lef transcription factor, leading to the upregulation of many genes responsible for cell proliferation.Activated beta-catenin and Tcf signaling by the accumulation of betacatenin in the cells has been implicated in human carcinogenesis."
19440933
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"Phosphorylation of beta-catenin by GSK3beta targets beta-catenin to ubiquitination and proteasome degradation XREF_BIBR."
20711340
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"Phosphorylation of beta-catenin by GSK3beta targets beta-catenin for ubiquitination and proteosome mediated degradation [XREF_BIBR - XREF_BIBR], which occurs within a large complex that involves Axin, the product of the adenomatous polyposis coli (APC) gene, protein phosphatase 2A, GSK3beta, and beta-TrCP [XREF_BIBR, XREF_BIBR]."
18822127
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"Phosphorylation of β-catenin by Gsk3β targets β-catenin to ubiquitination and proteasome degradation."
20140245
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"Treatment with the extract decreased the phosphorylation of β-catenin and increased expression of total β-catenin in human DPC cells."
32664659
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"In the absence of Wnt ligands, the β-catenin destruction complex phosphorylates β-catenin, which in turn leads to its ubiquitination and proteasomal degradation by the SCF UbL β-Transducin Repeat-Containing Protein (β-TrCP) ( xref , right )."
33218686
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"p.Glu54* and p.Phe99fs are located in the amino-terminal domain and predicted to lead to nonsense-mediated decay, while p.Arg449fs is located in the central armadillo repeat domain, which is essential for the phosphorylation of β-catenin by protein kinase CK2 (ref."
32989326
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"The β-catenin destruction complex phosphorylates the N-terminus of β-catenin through GSK3β and CK1α [124,125]."
35453784
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"As shown in Figures 6A–H, MDA-MB-231 and Hs-578T cells expressed high levels of YAP, total β-catenin and non-phosphorylated β-catenin (N-p-β-catenin, the activated form)."
39989901
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"GSK-3β and β-catenin play a central role in the Wnt/β-catenin signaling pathway and GSK-3β can phosphorylates β-catenin directly leading to the degradation of β-catenin [ 53 ], which blocked the activ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34428639
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"Previous studies have demonstrated that β-catenin is constitutively phosphorylated by the β-catenin destruction complex, which marks β-catenin for ubiquitination by a β-Trcp-containing E3 ubiquitin ligase complex ( xref ; xref )."
26456834
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"Gastrin significantly increased intestinal polyposis, but combination of PPI and gastrin markedly attenuated intestinal polyposis compared to gastrin promoted APCMin/+ mice (P <.001), in which significant beta-catenin phosphorylation and inhibition of beta-catenin nuclear translocation were observed with PPI alone or combination of PPI and gastrin, whereas gastrin treatment significantly increased beta-catenin nuclear translocation."
24563620
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"Although GSK3beta is able to phosphorylate beta-catenin thus marking the protein for degradation, neither changes in the levels of phosphorylated nor total beta-catenin was seen following re-exposure to the cocaine paired environment."
24595501
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"Under normal physiological conditions, cytoplasmic β-catenin is phosphorylated by the β-catenin destruction complex, which leads to its degradation in the proteasome."
34284111
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"In the absence of Wnt stimulation, a beta-catenin destruction complex consisting of adenomatous polyposis coli (APC), glycogen synthase kinase 3beta (GSK3beta) and AXIN phosphorylates beta-catenin, resulting in its ubiquitin mediated proteasomal degradation."
26452219
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"In the absence of Wnt, beta-catenin is phosphorylated by the beta-catenin destruction complex, a cytosolic multiprotein complex consisting of axin, GSK3, APC, etc.."
25609086
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"These cancers often contain mutations of either the APC gene or of the beta-catenin gene (CTNNB1) itself, which impedes the targeting phosphorylation of beta-catenin, freeing the protein from ubiquitination and its subsequent degradation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
12956888
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"Without a Wnt signal, the β-Catenin destruction complex binds and phosphorylates non-cadherin-associated β-Catenin."
26205886
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"As the destruction complex of β-catenin induces the phosphorylation of β-catenin, β-TrCP may detect increased levels of phosphorylated β-catenin."
37917550
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"The β-catenin destruction complex, which is formed by AXIN, APC (adenomatous polyposis coli) and GSK-3β (glycogen synthase kinase 3β), phosphorylates the β-catenin."
31153873
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"Dissociation of beta-catenin from the AJs, also due to SFK mediated phosphorylations of VE-cadherin and beta-catenin results in its nuclear localization and suppression of claudin gene transcription."
27245276
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"The beta-catenin destruction complex comprised of GSK-3, Axin and APC can bind to and phosphorylate beta-catenin, which is followed by its proteasomal degradation [XREF_BIBR]."
28969700
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"If so, then the loss of PS may indirectly promote GSK-3 mediated phosphorylation of β-catenin by neither sequestering β-catenin nor GSK-3."
19137062
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"Normally, β-catenin is phosphorylated by GSK-3β, which triggers the proteasome-mediated degradation of β-catenin [ 19 ]."
35998547
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"We found that LGK974 downregulated phosphorylation of the WNT co-receptor LRP6 and in parallel triggered the accumulation of Axin1, a member of the beta-catenin destruction complex, which with APC promote, the ubiquitin dependent proteasomal degradation of beta-catenin via CK1alpha- and GSK3beta mediated phosphorylation of beta-catenin XREF_BIBR - XREF_BIBR."
29895949
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"In the absence of Wnt stimuli, β-catenin is constitutively phosphorylated by the β-catenin destruction complex consisting of axin, adenomatous polyposis coli (APC) and glycogen synthase kinase 3β [GSK3β]."
21210154
sparser
"Without WNT ligand stimulation, the β-catenin destruction complex (made up of axin, APC, CK1α, and GSK-3β) phosphorylates β-catenin, causing its proteasomal degradation."
29207896
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"Since GSK3 is a kinase within the β-catenin destruction complex, which could phosphorylate Axin-bound β-catenin and the phosphorylated β-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of β-catenin target genes xref , xref , GSK3 can act as a negative regulator of β-catenin."
29497056
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"In addition, knockdown of beta-catenin reduced beta-catenin phosphorylation in A549/WT cells (XREF_FIG)."
26860078
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"This results in the inhibition of β-catenin phosphorylation and accumulation of β-catenin in the cytoplasm followed by translocation into the nucleus to regulate the target gene transcription in cooperation with TCF and LEF family transcription factors."
23471552
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"This section revealed that β-catenin and p -β-catenin(S45/Y333) played important role in the expression and activity of MMP9 and MMP7 in U87 and U251 cells."
28111262
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"The results showed that wild-type Htt functions as a scaffold protein, promoting β -catenin phosphorylation by the β -catenin destruction complex [ xref ]."
37780577
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"We also found that treatment with DHA combined with wild-type or mutant p53 showed different effects on the expression of β-catenin and p –β-catenin(Y333) in U87 and U251 cells."
28111262
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"When it is in an inactive state, beta-catenin is phosphorylated by the beta-catenin destruction complex assembled by APC/GSK-3beta/CKIalpha/Axin, leading to its degradation by ubiquitination."
32566019
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"Phosphorylation of beta-catenin by GSK-3beta targets beta-catenin for ubiquitination and degradation, thereby terminating the signal [XREF_BIBR]."
21601837
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"APC is a regulator of the assembly of the β-catenin destruction complex, which promotes β-catenin phosphorylation and ubiquitination and leads to its proteasome degradation [14]."
40061138
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"In the cytoplasm, the transcriptional co-activator β-catenin is phosphorylated by an axin/GSK3β-dependent β-catenin destruction complex, resulting in ubiquitin-mediated proteasomal degradation."
33587034
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"Of interest, GSK3β is an essential regulator of β-catenin, which constitutively phosphorylates cytosolic β-catenin (Ser33/37/Thr41) for proteasomal degradation ( Huelsken and Birchmeier, 2001 )."
31015047
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"These findings indicate that β-catenin is a downstream effector of HOTAIR.To verify the role of β-catenin in HOTAIR-mediated TMZ resistance, we treated HOTAIR-silenced U251R cells with a β-catenin agonist, SKL2001, which inhibits the phosphorylation and degradation of β-catenin ."
39482401
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"They demonstrate that binding to GSK3beta and to beta-catenin, which was reported to stimulate beta-catenin phosphorylation in vitro, is not sufficient in vivo either for beta-catenin degradation or for inhibition of its signaling."
10330403
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"This process is dependent on the β-catenin pathway, where LPA enhances GSK3β phosphorylation, β-catenin nuclear translocation, and cellular migration."
36749355
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"When the Wnt pathway is inactive, the β-catenin degradation complex, sometimes referred as degradosome, phosphorylates free cytoplasmic β-catenin, making it susceptible to ubiquitination and proteasome degradation [11,28,29]."
37047705
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"Relatedly, activated beta-catenin has been shown to be up-regulated in the nuclei of myofibroblasts of fibroblastic foci of IPF patients [XREF_BIBR], and alveolar epithelial responses to TGF-beta involve alpha3 integrin for beta-catenin phosphorylation and formation of a beta-catenin and p-Smad 2 complex resulting in initiation of EMT [XREF_BIBR]."
22838404
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"The Wnt/β-catenin signaling pathway in humans is rendered inactive by the β-catenin degradation complex, which phosphorylates β-catenin proteins and facilitates their ubiquitinated degradation."
40225869
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"The β-catenin destruction complex phosphorylates the N-terminus of β-catenin through GSK3β and CK1α [ xref , xref ]."
35453784
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"In order to understand the leading cause of β-catenin accumulation, they have performed immune-coprecipitation studies, demonstrating that wild type Htt acts as a scaffold protein, which promotes β-ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27370940
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"Supplementary Fig. 1 Total cell lysates isolated from PC3 cells transfected with pEV and pshNcad were used to determine the expression of Twist, Snai1, beta-catenin, phosphorylated beta-catenin and GA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21855541
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"Hence, Caco-2 cells harbor an APC mutation, whereas HCT-116 cells harbor a single amino acid deletion (CTNNB1 p.S45del) which prevent beta-catenin phosphorylation and degradation by the proteasome."
26107817
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"Beta-catenin translocation after Wnt activation can also be mediated through the sequestration of GSK3, the protein that phosphorylates and destabilizes beta-catenin, inside multivesicular endosomes [XREF_BIBR]."
28974015
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"The upstream kinase of p65, IKKβ is also a β-catenin kinase that phosphorylates the conserved degron motif to prime the β-catenin for β-transducing repeat-containing protein (βTrCP)-mediated ubiquitination and degradation in MSCs."
30510839
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"Interestingly, IKKβ is a β-catenin kinase that can directly phosphorylate the conserved degron motif of β-catenin to prime it for β-TrCP-mediated ubiquitination and degradation (10, 55)."
34957242
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"GSK-3β is a key component of β-catenin destruction complex that phosphorylates β-catenin and presents the protein for degradation."
20457486
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"In the OFF state, or in the absence of extracellular Wnt ligands, cytoplasmic beta-catenin is sequentially phosphorylated by the beta-catenin destruction complex (DC) composed of casein kinase 1a (CK1), glycogen synthase kinase 3 (GSK-3), the scaffold protein axin, and the tumor suppressor adenomatous polyposis coli (APC)."
27226375
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"Our results demonstrate that IBC inhibited CRC cell proliferation by inhibiting β-catenin signaling.Phosphorylation of β-catenin by GSK-3β leads to proteasomes-mediated degradation of β-catenin in the cytosol."
31118579
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"In the absence of wnt, β-catenin is phosphorylated by the β-catenin destruction complex and targeted for proteasomal degradation."
25371494
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"In normal cells the degradation of beta-catenin is regulated by Wnt signaling : beta-catenin is constitutively phosphorylated by the beta-catenin destruction complex, which marks beta-catenin for ubiquitination followed by rapid proteasomal degradation; Wnt signaling inactivates the beta-catenin destruction complex, thereby inhibiting phosphorylation of beta-catenin and consequently ubiquitination and degradation of the protein."
26456834
sparser
"When it is in an inactive state, β-catenin is phosphorylated by the β-catenin destruction complex assembled by APC/GSK-3β/CKIα/Axin, leading to its degradation by ubiquitination."
32566019
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"Β-catenin is sequentially phosphorylated and targeted for proteasomal degradation by members of the β-catenin destruction complex."
35663403
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"Previous studies have demonstrated that beta-catenin is constitutively phosphorylated by the beta-catenin destruction complex, which marks beta-catenin for ubiquitination by a beta-Trcp-containing E3 ubiquitin ligase complex."
26456834
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"16 When the pathway is inactive, beta-catenin is phosphorylated and targeted to degradation by the beta-catenin destruction complex."
27441654
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"DVL activation inhibits the β-catenin destruction complex (composed of APC, Axin, CK1, and GSK-3β), which normally phosphorylates β-catenin, marking it for ubiquitination and degradation ."
39874091
reach
"Axin2 scaffolds a group of Wnt regulating proteins known as the beta-catenin destruction complex, which poly-phosphorylates beta-catenin."
28588489
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"The siRNA-mediated downregulation of DHHC9 upregulated the expression of β-catenin and its active form and Cyclin D1, but suppressed the phosphorylated β-catenin (Fig. 4d)."
37865665
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"APC regulates beta-catenin levels by forming a complex with beta-catenin, Axin, and GSK3beta that leads to the phosphorylation of beta-catenin and its degradation through ubiquitin mediated proteolysis."
14662741
reach
"In the absence of Wnt, β-catenin undergoes proteolytic degradation by β-catenin destruction complex consisting of axis inhibition protein (AX-IN), adenomatous polyposis coli (APC), and glycogen synthase kinase 3 beta (GSK3β) phosphorylates β-catenin [78]."
36769365
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"Nonphosphorylated β-catenin antibody, which specifically recognizes residues encoded by exon 3, only detects the wild-type β-catenin from noncardiomyocytes (Figure 6D)."
36337924
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"The upstream of beta-catenin, glycogen synthase kinase 3beta (GSK-3beta) destruction complex, suppresses the phosphorylation of beta-catenin."
28790389
reach
"Deleting exon 3 of β-catenin results in the production of a truncated β-catenin protein preventing GSK-3β mediated β-catenin phosphorylation and degradation."
40290123
sparser
"In the absence of Wnt ligands, the intracellular β-catenin destruction complex (mainly composed of APC, Axin1/2, GSK3β and CK1α) phosphorylates β-catenin."
38254219
sparser
"Fig. 7 shows plots of the Wnt “On” to Wnt “Off” ratios of the computed levels of free unphosphorylated β-catenin, CK1 phosphorylated β-catenin and GSK3β phosphorylated β-catenin bound to the Destructi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30110600
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"Phosphorylation of beta-catenin by GSK3beta targets beta-catenin for ubiquitination and subsequent degradation XREF_BIBR."
19159010
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"AKT2 upregulated β-catenin phosphorylation and LKB1 inhibited AKT2-induced β-catenin phosphorylation in ATDC5 cells (Fig.1A)."
36439631
sparser
"Knocking down LINC00839 significantly inhibited the interaction between c-Src and β-catenin, as well as β-catenin Y654 phosphorylation level, indicating that LINC00839 tied c-Src and β-catenin together, promoting β-catenin phosphorylation."
37438359
sparser
"C-T conversion of a single base in the CTNNB1 gene prevented phosphorylation and degradation of β-catenin protein, leading to a 7-fold increase of β-catenin levels in HEK293T cultures."
32733204
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"It was further proposed that Rac1, JNK2, and β-catenin form a complex in the cytoplasm and JNK2 phosphorylates β-catenin to promote its nuclear translocation , although it remains unclear how Rac1, normally linked to Wnt/Fz-PCP signaling , is involved in canonical Wnt-signaling."
30546012
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"The β-catenin destruction complex is ineffective in phosphorylating and degrading β-catenin resulting in nuclear translocation of β-catenin [2]."
32488834
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"GSK-3β, as well as Axin and casein kinase 1α, constitutes a β-catenin destruction complex, which recruits β-catenin into this complex and phosphorylates β-catenin, leading to subsequent ubiquitination[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27840063
sparser
"Kolegraff et al xref xref demonstrated that down-regulation of DSC2 activated the EGFR/Akt pathway, which caused the accumulation of phosphorylated β-catenin in the nucleus and phosphorylated β-catenin could activate the downstream target genes, resulting in the abnormal proliferation and invasion of tumor cells."
33204158
sparser
"It is well known that serine-phosphorylation of beta-catenin by the Axin-glycogen synthase kinase (GSK)-3beta complex targets beta-catenin for ubiquitination-degradation, and mutations at critical phosphoserine residues stabilize beta-catenin and cause human cancers."
10339577
sparser
"To examine the potential relationship between two subtypes of VLDLR and β-catenin, we analyzed the expression of β-catenin and phosphorylated β-catenin."
19167408
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"Phosphorylation of beta-catenin at Serine37 by GSK-3beta targets beta-catenin for degradation."
26908451
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"Axin promotes the formation of a complex comprising itself, glycogen synthase kinase-3beta (GSK-3beta), adenomatous polyposis coli (APC) and beta-catenin, which in turn enhances the phosphorylation of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12185851
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"Beta-catenin itself is also a likely target for GSK3, since wild-type GSK3 phosphorylates beta-catenin at a conserved site whose mutation increases its stability (Yost et al. 1996)."
9039260
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"GSK-3β induces serine/threonine phosphorylation of β-catenin and promotes the degradation of phosphorylated β-catenin via the ubiquitin/proteasome pathway [43] ."
18423982
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"Finally, the β-catenin destruction complexes are disassembled, which allows unphosphorylated β-catenin to accumulate and subsequently translocate to the nucleus ."
30451837
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"Axin2, a Wnt signaling upstream gene of beta-catenin, efficiently supports the GSK3beta dependent phosphorylation of beta-catenin in normal cells, which subsequently marks the posttranslationally modi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25305448
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"Deletions of exon 3 of CTNNB1 or mutations prevent beta-catenin phosphorylation, and thus its degradation leads to an increase in both cytoplasmic and nuclear beta-catenin protein levels, which results in the constitutive activation of the Wnt/beta-catenin pathway (Figure 2)."
31547062
sparser
"In the absence of Wnt (Wnt-off), β-catenin is phosphorylated by the β-catenin degradation complex."
35279748
sparser
"In the absence of WNTs, a complex between Axin, APC, GSK-3β, and β-catenin causes the phosphorylation of β-catenin by GSK-3β and targets it for degradation ( xref )."
14734535
sparser
"GSK3β is the key component of the β-catenin degradation complex, which phosphorylates β-catenin for subsequent ubiquitination and degradation."
31838050
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"Activation of Wnt and beta-catenin signaling occurs upon binding of Wnt to the receptors, thus causing hypophosphorylation of its substrate, beta-catenin (Hay, et al., 2004)."
22151351
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"Serine 45 (S45) of β-catenin is phosphorylated by CKIα, which primes β-catenin for subsequent phosphorylation at sites 33, 37, and 41 by GSK-3 ( Amit et al., 2002; Zeng et al., 2005 )."
17543867
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"In the absence of an extracellular Wnt stimulus the β-catenin destruction complex, which is composed of casein kinase 1 alpha (CK1α) and glycogen synthase kinase 3 (GSK3), and scaffolding proteins ade[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25446263
sparser
"GSK3β is a component of the β-catenin destruction complex which phosphorylates β-catenin leading to its ubiquitination and degradation by the proteasomal pathway xref , xref ."
23285165
sparser
"In this context, we investigated the protein levels of total β-catenin and phosphorylated β-catenin in HEK-293 and Neuro-2a cells after incubation with GO-treated media ( xref )."
31731544
reach
"This enables the accumulation of β-catenin due to the inhibition of GSK3 mediated β-catenin phosphorylation and subsequent proteasomal degradation (Taelman et al., 2010)."
36685192
sparser
"Wnt/β-catenin signaling pathway was also examined by analyzing the expression of total β-catenin and phosphorylated β-catenin in cytoplasm, and the results showed that the growth inhibitory effects of oxymatrine treatment on MCF-7 cells may be due to the inhibition of SP and Wnt/β-catenin signaling pathway."
21069479
sparser
"In the absence of WNT signaling, the β-catenin destruction complex phosphorylates β-catenin, leading to subsequent proteasomal degradation of the protein."
33425886
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"In the absence of Wnt ligands, β-catenin is phosphorylated by the β-catenin destruction complex of Axin2, adenomatous polyposis polyps, and glycogen synthase kinase-3β, and phosphorylated β-catenin is then ubiquitinated and degraded by proteasomes."
35563281
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"We will also cover the major progress achieved through intense research about ability of cucurbitacins to inhibit cancer development and progression.In the coming sections, we review how regulation of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33152487
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"The key components of this destruction complex include the scaffold protein Axin, beta-catenin binding protein adenomatous polyposis coli, protein kinases casein kinase (CK) 1 alpha and delta and glycogen synthase kinase-3 (GSK-3alpha and beta) that continuously phosphorylate beta-catenin."
33163244
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"It was previously well documented that Axin2, a beta-catenin and TCF signaling target molecule, could enhance the phosphorylation of beta-catenin and induce proteasomal degradation of beta-catenin, fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24975844
sparser
"In the absence of Wnt ligand binding (or inactive state), β-catenin is phosphorylated by β-catenin destruction complex proteins, including axin, adenomatous polyposis coli, glycogen synthase kinase-3 β, and casein kinase-1 [ xref ]."
33799644
reach
"Beta-catenin is phosphorylated by CK1alpha and glycogen synthase kinase (GSK)-3beta in a complex that contains APC and axin, targeting beta-catenin for ubiquitination and degradation XREF_BIBR."
19190323
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"Given the critical role of GSK3β in the regulation of the stability of β-catenin by phosphorylation on S33/S37/T41, we examined whether β-catenin isoforms, phosphorylated by GSK3β, are increased in HBL.No detectable phosphorylation of β-catenin on S33/S37/T41 residues was found in either the background or tumor sections (Figure 1C, Supplementary Figure S9)."
36551548
sparser
"Magnolol inhibited AKT phosphorylation of GSK-3β, thus more β-catenin was phosphorylated by GSK-3β and more β-catenin was degraded by the Ubiquitin–Proteasome Pathway."
30798160
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"The Wnt/β-catenin signaling pathway in humans is rendered inactive by the β-catenin degradation complex, which phosphorylates β-catenin proteins and facilitates their ubiquitinated degradation."
40225869
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"CKIdelta directly phosphorylates numerous components of the beta-catenin degradation complex in vitro, i.e., Dsh, APC, axin, and beta-catenin, and CKIepsilon phosphorylates axin and beta-catenin in vivo XREF_BIBR."
19440376
sparser
"In the so called OFF-state Wnt signalling is not present, and β-catenin is phosphorylated by the Wnt/ β-catenin inhibitory complex through the scaffolding proteins of Axin and APC."
34348663
sparser
"In the absence of Wnt ligands, β-catenin is phosphorylated by the β-catenin destruction complex of Axin2, adenomatous polyposis polyps, and glycogen synthase kinase-3β, and phosphorylated β-catenin is then ubiquitinated and degraded by proteasomes."
35563281
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"As Akt phosphorylates both GSK-3β and β-catenin, GSK3β is inhibited and β-catenin is activated, thereby activating the Wnt/β-catenin pathway (38)."
34055054
reach
"Mutations in APC or beta-catenin lead to dissociation of the complex, causing the accumulation of nonphosphorylated beta-catenin, which translocates to the nucleus and acts as a transcriptional coactivator of TCF transcription factors (Kinzler and Vogelstein, 1996; Bienz and Clevers, 2000)."
14710233
reach
"When Wnt ligands are absent, intracellular β-catenin is first phosphorylated by the intracellular β-catenin destruction complex and subsequently ubiquitinated by β-TrCP to be finally degraded at the proteasomal level."
39199632
sparser
"Phosphorylated Akt, total Akt, N-cadherin, α-catenin, β-catenin, and tyrosine phosphorylated β-catenin were analyzed by immunoblotting with specific Abs as described [14,18] ."
19501458
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"Therefore, our results raise the possibility that PAK4 promotes the TCF/LEF activity induced by β-catenin, at least in part, through phosphorylation of β-catenin on Ser675.We examined whether the PAK4[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22173096
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"Analysis of nuclear β-catenin fluorescence intensity demonstrated that latrunculin treatment increased β-catenin fluorescence intensity of both total and nonphosphorylated β-catenin by ∼50% (48.6 ± 23.7% and 45.9 ± 10.2%, respectively), while jasplakinolide treatment did not alter nuclear staining intensity (Fig. 7, A and B)."
30867227
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"In order to understand the leading cause of β-catenin accumulation, they have performed immune-coprecipitation studies, demonstrating that wild type Htt acts as a scaffold protein, which promotes β-ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27370940
reach
"Also, if Wnt signaling is activated, β-catenin degradation is blocked due to the decreased ability of GSK-3β to phosphorylate β-catenin [8] ."
21763403
reach
"In this pathway, APC and glycogen synthase kinase 3 beta (GSK3β) combined with Wnt pathway key regulator β-catenin induces β-catenin phosphorylation and degradation to avoid Wnt pathway over-activation."
34540977
reach
"This recruitment inactivates the beta-catenin destruction complex, which is conformed by protein Axin, tumor-suppressor adenomatous polyposis coli gene product (APC), CK1, and GSK3beta, thus preventing beta-catenin phosphorylation by GSK3 and consequently, its proteasomal degradation."
28203237
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"We explored whether the AKT/ β-catenin axis mediated the effects of miR-708.First, we found that SPHK2 overexpression increased phosphorylated Akt, phosphorylated GSK3-β and β-catenin levels, whereas SPHK2 inhibition decreased phosphorylated Akt, phosphorylated GSK3-β, and β-catenin levels in glioma cells (Fig. 6a)."
31171769
reach
"In the absence of Wnt ligand, β-catenin may be phosphorylated by the β-catenin destruction complex composed of Axin, glycogen synthase kinase 3β (GSK3β), casein kinase 1α (CK1α), and adenomatous polyposis coli (APC) and subsequently degraded by the E3 ligase β-TrCP [246]."
36694209
reach
"Moreover, Celastrol treatment further enhanced the association of YAP and β-catenin and YAP-induced β-catenin phosphorylation (Figure 3D)."
31040884
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"This leads to the inhibition of the “β-catenin destruction complex” formed by Axin, GSK-3β, APC, and CK1, which no longer phosphorylates β-catenin, resulting in translocation of β-catenin to the nucle[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33964281
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"Obviously, this is reminiscent of the scaffolding function of axin during beta-catenin phosphorylation by the beta-catenin kinases CK1alpha and GSK3."
29438981
reach
"As seen in our study, the majority of CTNNB1 mutations affect the GSK3beta binding sites for beta-catenin, which ultimately influences the ability of GSK3beta to phosphorylate beta-catenin and signal its degradation."
23765252
sparser
"As mentioned, β-catenin is phosphorylated by the β-catenin destruction complex consisting of APC, Axin1 and GSK3β, which is maintained at low levels through targeted ubiquitination and proteasomal degradation [ xref , xref , xref ]."
35269974
reach
"Mutations in APC or beta-catenin lead to dissociation of the complex, causing accumulation of unphosphorylated beta-catenin, which translocates to the nucleus and acts as a transcriptional coactivator of TCF transcription factors [XREF_BIBR, XREF_BIBR]."
29050252
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"Typical for this pathway is formation of a protein complex consisting of active GSK-3β, adenomatous polyposis coli (APC), axin and β-catenin, in which GSK-3β phosphorylates β-catenin and targets it fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19703560
sparser
"In addition, Caspi et al. (2008) , using colorectal cell lines that express a mutant form of β-catenin which cannot be phosphorylated by GSK-3β and ectopically expressed mutant β-catenin protein, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21035499
reach
"In canonical pathway, Wnt3A has been known to stabilize beta-catenin through the dissociation between beta-catenin and glycogen synthase kinase-3beta (GSK-3beta) that suppresses the phosphorylation and degradation of beta-catenin."
27575935
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"XREF_FIG C, bottom panel, shows that, EGF stimulation of HA tagged beta-catenin led to a similar level of Tyr 654 phosphorylation of beta-catenin; however, co-stimulation with IL-2 led to disruption of interactions between HA tagged beta-catenin and Hif1alpha, which were reversed by mutation of Jak3 mediated phosphorylation sites (Y30F, Y64F, Y86F) in beta-catenin (XREF_FIG C, top panel)."
28821617
sparser
"The β‐catenin destruction complex phosphorylates β‐catenin, promoting its consequent ubiquitination and proteasomal degradation."
39022865
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"Furthermore, EGF also promoted disruption of HA tagged beta-catenin with the AJ protein alpha-catenin, which was again reversed by mutation of Jak3 mediated phosphorylation sites (Y30F, Y64F, Y86F) in beta-catenin (XREF_FIG C, center panel)."
28821617
reach
"The GSK3 enzyme plays a pivotal role in the β-catenin signaling pathway, which is responsible for the phosphorylation and degradation of β-catenin through ubiquitin proteasome [33]."
36077052
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"Axin acts as a scaffolding protein in the β-catenin destruction complex, and brings together GSK3β and β-catenin, which enhances β-catenin phosphorylation and subsequent degradation [58] ."
34989786
reach
"The so-called β-catenin destruction complex consists of axin, β-catenin, and APC and phosphorylates β-catenin with the help of CK1α and GSK-3β [75]."
39125758
sparser
"When Wnt cannot bind with dual receptors (LRP5/6 and Frizzled 7), the level of β-catenin will be reduced by the β-catenin destruction complex which phosphorylates β-catenin, leading to ubiquitination and further degradation of β-catenin [ xref , xref ]."
33105778
reach
"In the absence of the Wnt ligand or in the presence of a Wnt antagonist, a multi-protein β-catenin destruction complex, which includes Axin, APC (adenomatous polyposis gene), glycogen synthase kinase 3 beta (GSK3β), and casein kinase alpha (CKIα), hyper-phosphorylates β-catenin."
32226020
reach
"A second proposes that GSK3 and beta-catenin are spatially separated by the uptake of GSK3 into multivesicular bodies (MVBs), preventing cytoplasmic beta-catenin phosphorylation [XREF_BIBR]."
27284979
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"11,12 In summary, all six SN-HPCs harbored mutations abrogating the phosphorylation and subsequent proteasomal degradation of beta-catenin by the beta-catenin disruption complex, which is consistent w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25482924
reach
"In addition, beta-catenin oncogenic mutations have been reported in approximately 10% of colorectal cancer patients, and these missense or deletion mutations are located at beta-catenin sites where GSK3beta normally phosphorylates beta-catenin, leading to stable beta-catenin translocation into the nucleus for Wnt activation [XREF_BIBR, XREF_BIBR]."
28356914
sparser
"The β-catenin destruction complex, which is formed by AXIN, APC (adenomatous polyposis coli) and GSK-3β (glycogen synthase kinase 3β), phosphorylates the β-catenin."
31153873
reach
"Pretreatment with 1,25 (OH) 2 D 3 and LY294002 (phosphoinositide 3-kinase [PIK3] inhibitor) significantly inhibited the IS induced phosphorylation of Akt and beta-catenin, nuclear beta-catenin accumulation, and EMT associated protein expression."
31536856
sparser
"In the absence of Wnt ligands, a complex between Axin, adenomatous polyposis coli (APC) tumor suppressor protein, casein kinase (CK) 2, glycogen synthase kinase (GSK) 3β, and β-catenin causes the phosphorylation of β-catenin by GSK3β and targets it for subsequent degradation by the proteasome xref , xref ( xref )."
28408959
reach
"In the absence of signaling, the beta-catenin destruction complex that includes axis inhibition protein (Axin), adenomatous polyposis coli (APC), casein kinase 1 alpha (CK1alpha), and glycogen synthase kinase 3 (GSK3) mediates beta-catenin phosphorylation."
26864984
reach
"Wnt and beta-catenin pathway, also termed the canonical Wnt pathway, is activated upon the binding of Wnt ligands to a dual receptor complex comprising low-density lipoprotein receptor related protein 5 or 6 (LRP5/6) co-receptors and the frizzled receptor at the cell membrane, causing the suppression of glycogen synthase kinase-3beta (GSK3beta) activity and preventing phosphorylation of beta-catenin and its proteosomal degradation."
33409280
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"In normal cells, β-catenin destruction complex, which is composed of APC, AXIN, glycogen synthase kinase-3β (GSK3β) and casein kinase1α (CK1α), phosphorylates β-catenin, resulting in its ubiquitylatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38216082
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"These results are consistent with insulin-driven β-catenin accumulation relying on Akt-induced Gsk3β inactivation and not on Akt-dependent or independent phosphorylation of β-catenin at these residues[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25091498
reach
"We demonstrate that HUWE1 enhances WNT/CTNNB1 signaling through two distinct mechanisms: by antagonizing DC-mediated CTNNB1 phosphorylation and degradation, and through another mechanism independent of CTNNB1 stability."
38410441
sparser
"When Wnt ligands are absent, intracellular β-catenin is first phosphorylated by the intracellular β-catenin destruction complex and subsequently ubiquitinated by β-TrCP to be finally degraded at the proteasomal level."
39199632
reach
"The level of beta-catenin in cells is tightly controlled by its degradation complex composed of Axin, APC, GSK-3beta, and beta-catenin, in which GSK-3beta phosphorylates beta-catenin and thus triggers its ubiquitination and subsequent proteasomal degradation."
21423639
reach
"Phosphorylation of beta-catenin by GSK-3beta targets beta-catenin for ubiquitination and proteasome mediated degradation."
12969793
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"Interaction of WNT and FZ/LRP receptors promotes hyperphosphorylation of DVL, and inhibits the beta-catenin degradation complex made up of adenomatous polyposis coli (APC), GSK3beta and the scaffold protein AXIN1, effectively blocking phosphorylation and degradation of cytoplasmic beta-catenin."
26130815
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"This finding unravels the molecular mechanism underlying the neuroprotective effect of liraglutide in arresting diabetic retinal neurodegeneration, that is, via binding to GLP-1R from which G beta gam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31015047
reach
"In the absence of Wnt stimuli, beta-catenin is constitutively phosphorylated by the beta-catenin destruction complex consisting of axin, adenomatous polyposis coli (APC) and glycogen synthase kinase 3beta [GSK3beta]."
21210154
reach
"FRAT1 has been identified as a positive regulator of the Wnt and beta-catenin pathway, which can inhibit the GSK-3-mediated phosphorylation of beta-catenin XREF_BIBR, XREF_BIBR, XREF_BIBR."
23613813