IndraLab

Statements

Progesterone inhibits KCNH2. 4 / 5
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"Thus, it follows that progesterone and cholesterol affect Sig-1R actions and reduce hERG channel maturation.Similar results have been obtained for SK3 channels, the small-conductance calcium-activated potassium channels, for which expression of these proteins is regulated by the cellular content of Sig-1R and cholesterol (Gueguinou et al., 2017)."
31068816
ctd
No evidence text available
21525004
reach
"Progesterone also concentration-dependently decreased HERG current density, but had no effect on voltage gated L-type Ca (2+) and K (+) channels."
21525004
reach
"By using HEK293 cells stably-expressing hERG channels and whole-cell voltage clamp recordings, it has been demonstrated that progesterone decreases hERG current-density."
31068816