IndraLab

Statements

USP18 inhibits activity. 4 / 4
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"For example, the expression of USP18, which is an inhibitor of antiviral activity of IFN- λ, was elevated in liver biopsies of HCV patients who carried the ΔG allele and were thus capable of producing IFN- λ4 (28)."
33133009
sparser
"In this screening, USP18 and USP21 significantly inhibited RIG-I-CARD–induced IFN-β reporter activity, whereas other USPs had no effect or fewer effects ( xref )."
24493797
sparser
"This findings suggest that USP18 inhibits I-IFN-mediated hepatocyte antiviral activity and may be involved in the immune tolerance of chronic hepatitis virus infection."
28709980
sparser
"In vitro experiments demonstrated that USP18 inhibited BV2 microglial activity and reduced the mRNA and protein levels of NF-κB, JAK1, p-JAK1, STAT1, and p-STAT1 in BV2 microglial cells."
31513843