IndraLab

Statements

COPS6 activates Carcinogenesis. 7 / 8
| 1 6
eidos
"CSN6 promotes GBM proliferation , migration , invasion , and tumorigenesis through upregulation of EGFR by blocking its ubiquitination ; this happens as a result of interactions with CHIP that cause its degradation , although CHIP auto-ubiquitination occurs through an unknown mechanism [ 91 ] ."
33665742
reach
"In addition to the ubiquitin-dependent degradation of proteins, Jab1/CSN5 and CSN6 promote tumorigenesis via ubiquitin independent proteasomal degradation of the cell cycle regulators p16 and p14ARF ."
35315259
reach
"In addition, studies shown that CSN6 has the function of deubiquitinase and promoted tumorigenesis, proliferation, metastasis and EMT by inhibiting substrates degradation [ 14–16 ]."
32289284
reach
"9e Besides, we also found that CSN6 promotes tumorigenesis in mice through directly stabilization of MDM2."
38308184
reach
"For example, tumorigenesis is caused by mutations of CSN5 and CSN6."
39600336
reach
"Abnormalities in the appeal pathway may be the main cause of 5-FU resistance, for example, a recent study by Zou et al. found that CSN6 promotes colorectal carcinogenesis and chemotherapy tolerance by mediating nucleotide metabolism ."
39747340
reach
"CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16 INK4a ."
31565481