IndraLab
Statements
Calcium_channels binds Sodium_channels and CACNA1S. 2 / 2
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2
sparser
"HypoPP is associated with mutations in calcium channel ( CACNA1S ; 60% of kindreds) and sodium channel ( SCN4A ; 20% of kindreds) genes. xref – xref The clinical presentation is identical for patients with HypoPP caused by calcium or sodium channel mutations because homologous gene defects of either channel cause an anomalous leakage current, which is active at the resting potential and produces susceptibility to paradoxical depolarization of the fiber and inexcitability in the setting of low extracellular K + (2.5 to 3.5 Meq/L). xref , xref "
sparser
"HypoPP is associated with mutations in calcium channel ( CACNA1S ; 60% of kindreds) and sodium channel ( SCN4A ; 20% of kindreds) genes. xref , xref , xref , xref , xref The clinical presentation is identical for patients with HypoPP caused by calcium or sodium channel mutations because homologous gene defects of either channel cause an anomalous leakage current, which is active at the resting potential and produces susceptibility to paradoxical depolarization of the fiber and inexcitability in the setting of low extracellular K + (2.5 to 3.5 Meq/L). xref , xref "