IndraLab

Statements

HPC increases the amount of USP22. 4 / 4
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"Despite that USP22 was detectable in both nucleus and cytoplasm of CA1 cells, cytoplasmic USP22 exhibited no significant change in our ischemic model, whereas HPC restored the tGCI-induced downexpression of nuclear USP22."
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"Hence, it is worth investigating whether HPC induces USP22 expression in CA1 to catalyze nuclear β-catenin deubiquitination, thereby promoting nuclear β-catenin stabilization and mediating neuroprotection against tGCI.Herein we aim to explore the mechanisms by which HPC regulates β-catenin ubiquitination to stabilize nuclear β-catenin in CA1 after tGCI."
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"On the other hand, HPC increases USP22 expression to induce the deubiquitination of nuclear β-catenin, thereby inhibiting the degradation of nuclear β-catenin to enhance nuclear β-catenin stability and finally promoting neuronal survival after tGCI."
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"On the other hand, HPC increased the expression of USP22 within the neuronal nucleus in CA1 after ischemia to promote nuclear β-catenin deubiquitination."
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