IndraLab

Statements

SCN5A binds type 3. 4 / 4
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"Type 3 LQTS (LQT3) is associated with mutations in the SCN5A gene, which codes for the Na + voltage-gated channel. xref "
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"SCN5A mutations associated with long QT syndrome type 3 (LQT3) lead to enhanced late sodium current and consequent action potential (AP) prolongation."
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"Long QT syndrome type 3 (LQT3) is associated with genetic modifications of the Scn5a gene, which interfere with Na + channel inactivation and lead to persistent, arrhythmogenic late Na + currents ( xref )."
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"However, sinus node dysfunction has also been reported in patients with gain-of-function SCN5A mutations associated with long QT syndrome type 3 (LQT3) in apparent overlap with the previous examples ( xref )."
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