IndraLab

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SCN5A binds type 3. 4 / 4
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"However, sinus node dysfunction has also been reported in patients with gain-of-function SCN5A mutations associated with long QT syndrome type 3 (LQT3) in apparent overlap with the previous examples ( xref )."
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"Long QT syndrome type 3 (LQT3) is associated with genetic modifications of the Scn5a gene, which interfere with Na + channel inactivation and lead to persistent, arrhythmogenic late Na + currents ( xref )."
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"Genotype–phenotype studies have shown that, in most cases, LQTS results from loss-of-function mutations in KCNQ1 (LQTS Type 1—LQT1) and KCNH2 (LQTS Type 2—LQT2) or gain of function in SCN5A mutations (LQTS Type 3—LQT3), all of which predispose young, otherwise healthy individuals to life-threatening arrhythmias [ xref , xref , xref , xref , xref ]."
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"Type 3 LQTS (LQT3) is associated with mutations in the SCN5A gene, which codes for the Na + voltage-gated channel. xref "
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