IndraLab

Statements

KCNH2 activates cell growth. 13 / 15
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"Moreover, the blocking of HERG channels dramatically impairs cell growth of HERG bearing tumor cells."
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"In addition, functional studies in head and neck squamous cell carcinoma derived cell lines further revealed that HERG1 expression promotes anchorage dependent and -independent cell growth and invasive capability, although independently of its ion conducting function."
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"Moreover, knockdown of hERG inhibits cell growth and induces apoptosis in ATC cells in vitro."
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"Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivo."
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"When the oxygen supply was restored, the HERG1B and HERG1ratio could be increased by a remodeling of HERG channels on the plasma membrane, thus leading to depolarize V m and sustain cell growth (Croci[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed in the present paper we provide evidence that hERG1 blockers could inhibit PDAC cell growth and migration in vitro."
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"HERG1 silencing, as well as miR-96 over-expression inhibits the PDAC cell growth and invasiveness in vitro, and reduces tumorigenicity in vivo."
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"Yet, a significant number of Tn positive cells were detected in these livers, indicating that the expression of ER-G1, in the absence of NRas, is not toxic but does not induce cell growth or prolifera[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This suggests that ER-G1 stimulates cancer cell proliferation by enabling tumor expansion rather than directly stimulating cell growth and division.Based on tumor morphology, we hypothesized that ER-G[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the same experiment, i.e., using the same controls, cell growth was reduced to a similar degree as with siHERG1 by inhibition of HERG channel protein expression with the short hairpin RNA against ERG1 (shRNA-U6)."
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"(i) hERG1 was expressed at high levels in 59% of primary PDAC; (ii) hERG1 blockade decreased PDAC cell growth and migration; (iii) hERG1 was physically and functionally linked to the Epidermal Growth Factor-Receptor pathway; (iv) in transgenic mice, ERG1 was expressed in PanIN lesions, reaching high expression levels in PDAC; (v) PDAC patients whose primary tumour showed high hERG1 expression had a worse prognosis; (vi) the alpha-hERG1-MoAb could detect PDAC in vivo."
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"Indeed, hERG1 blockage impairs tumor cell growth both in vitro and in vivo in preclinical mouse model."
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"HERG downregulation by continuous hypoxia ( CH ) inhibited cell growth and proliferation ."
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