IndraLab

Statements

CA2 activates KCNMA1. 7 / 7
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"Two of these putative Ca2 +-binding domains activate the BK channel when cytoplasmic Ca2+ reaches micromolar concentrations, and a low Ca2+ affinity mechanism may be involved in the physiological regulation by Mg2+."
17106573
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"BK channel activation by voltage and Ca2 + can be well described by the HA allosteric model ( Horrigan and Aldrich , 2002 ; Figure 8a ) ."
32597752
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"Although both of them are voltage-gated , SLO1 is additionally activated by Ca2 + [ 141 ] , whereas SLO3 is activated by an alkaline pHi [ 135,142 ] ."
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"BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site."
37130264
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"Repolarization following light-stimulation is markedly accelerated by Ca²(+)-dependent BK channel activation."
21399632
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"However , in cerebral arterial smooth muscle cells , Ca2 + sparks activate only BK channels ( Brenner et al ., 2000 ; Nelson et al ., 1995 ) ."
33452672
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"The Ca2 + spark is well known to be functionally coupled with a cluster of BK channels on the plasma membrane in CASMCs ; thus , Ca2 + spark may activate BK channels to produce a macroscopic outward current ( e.g ., spontaneous transient outward current , STOC ) that hyperpolarizes the cell plasma membrane and causes cerebral artery dilation [ 8] ."
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