IndraLab

Statements

USP10 activates AMPK. 10 / 11
| 7 3
reach
"USP10 mediates AMPKα deubiquitination, facilitating its phosphorylation at Thr172, thus, regulates metabolic homeostasis [218]."
40102846
reach
"USP10 acts as the hub in this process, thus enabling LKB1/AMPK to suppress tumor growth via regulation of both metabolism and cell proliferation."
37873736
reach
"USP10-mediated AMPK activation exerts a significant impact on the progression of diverse metabolic disorders."
38705504
reach
"We then explored the mechanism by which USP10 modulates AMPK activation, first by examining whether USP10 directly interacts with AMPK."
26876938
reach
"As shown in XREF_FIG, the phosphorylation of USP10 increased significantly after glucose starvation, suggesting that USP10 might be a substrate of AMPK."
26876938
sparser
"USP10 is involved in many physiological activities in the human body, such as promoting cell proliferation and differentiation by targeting p53 protein ( xref ); USP10 can activate the downstream protein AMPK through deubiquitination and form a feedforward loop with it ( xref )."
35875077
sparser
"Finally, USP10 deubiquitinates and activates the autophagy-promoting kinase AMPK ( xref )."
33577797
reach
"The fact that USP10 also positively regulates beclin-1 and AMPK would make pharmacologic activators of USP10 particularly effective as autophagy enhancers."
33577797
reach
"Only WT USP10, but not the CA mutant could rescue AMPK activation triggered by USP10 RNAi (XREF_FIG), suggesting that USP10 deubiquitinase activity is required for AMPK activation."
26876938
sparser
"However, the activation of AMPK induced by USP10 does not seem to be influenced by these peptides (Supplementary Fig. xref )."
35987808