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USP10 activates AMPK. 9 / 10
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"The fact that USP10 also positively regulates beclin-1 and AMPK would make pharmacologic activators of USP10 particularly effective as autophagy enhancers."
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"Finally, USP10 deubiquitinated and activated the autophagy-promoting kinase AMPK [53] ."
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"These results suggest that USP10 deubiquitinase activity is required for its effects in AMPK activation and cellular metabolism.We then explored the mechanism by which USP10 modulates AMPK activation,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Only WT USP10, but not the CA mutant could rescue AMPK activation triggered by USP10 RNAi (XREF_FIG), suggesting that USP10 deubiquitinase activity is required for AMPK activation."
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"As shown in Figure 4 B, the phosphorylation of USP10 increased significantly after glucose starvation, suggesting that USP10 might be a substrate of AMPK."
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"Finally, USP10 deubiquitinates and activates the autophagy-promoting kinase AMPK ( xref )."
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"We then explored the mechanism by which USP10 modulates AMPK activation, first by examining whether USP10 directly interacts with AMPK."
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"Only WT USP10, but not the CA mutant, could rescue AMPK activation triggered by USP10 RNAi, suggesting that USP10 deubiquitinase activity is required for AMPK activation."
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"As shown in XREF_FIG, the phosphorylation of USP10 increased significantly after glucose starvation, suggesting that USP10 might be a substrate of AMPK."
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