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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL5 activates IL1B. 2 / 2

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"We also showed that overexpression of UCH-L5 was associated with a significant increase in caspase-1 activity, while inhibition of UCH-L5 by selective inhibitor [XREF_BIBR] or UCH-L5 knock-down led to decrease in inflammasome dependent IL-1beta release in chicken as well as in human macrophages during infection with Salmonella and during inflammasome activation by lipopolysaccharide (LPS) and nigericin."

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"UCH-L5 inhibition down-regulates IL-1beta release during inflammasome activation in macrophages."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...