IndraLab

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"In short, these data suggest that GABA gavage reduces the number of proinflammatory M1 macrophages, thus suppressing inflammation and reducing cardiac injury after I/R.2.4 GABA Inhibited M1 Macrophage Polarization by Suppressing the Activation of NLRP3 Inflammasome."
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"GABA also blocked formation of NLRP3-ASC-Caspase-1 complex with immunofluorescence analysis ( Figure 1 G), which is a crucial platform for IL-1β production."
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"This indicates that GABA A receptors are not necessary for ethanol to inhibit Nlrp3 inflammasome activation."
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"We found that IL‐1β secretion was significantly increased by LPS stimulation compared to the vehicle group (p < 0.001) and this LPS‐stimulated increase of IL‐1β secretion was suppressed upon GABA treatment (p < 0.001) (Figure 6C), suggesting that GABA suppressed the activation of NLRP3 inflammasome induced by LPS."
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