IndraLab

Statements

STAT1 binds USP13. 18 / 18
2 | 2 14
sparser
"The ability of USP13(C343A) to remove ubiquitin molecules from STAT1 was decreased (Fig.  xref ), although USP13(C343A) still binds to STAT1 (Supplementary Fig.  xref )."
40593642
sparser
"Additionally, we reveal the protective role of the cardiomyocyte-specific USP13-STAT1 axis in myocardial hypertrophy, indicating that cardiac-specific gene therapy targeting USP13 could represent a promising therapeutic strategy for cardiac hypertrophy."
40593642
sparser
"These observations validated that USP13 directly binding STAT1 protein in cardiomyocytes."
40593642
sparser
"Usp13 mainly interacted with the nonactivated form of Stat1 ( xref )."
29685903
sparser
"This study illustrated a beneficial effect of USP13 in hypertrophic cardiomyocytes and identified a cardiomyocyte-specific USP13-STAT1 axis in regulating cardiac hypertrophy."
40593642
sparser
"Here, the authors show the beneficial effects of a cardiomyocyte-derived deubiquitinating enzyme, USP13, in hypertrophic cardiomyocytes and identify a cardiomyocyte-specific USP13-STAT1 axis in regulating cardiac hypertrophy."
40593642
biogrid
No evidence text available
23940278
biogrid
No evidence text available
23940278
reach
"Moreover, we observed substantial attenuation of the interaction between STAT1 and USP13 upon overexpression of Mbtps1 (Fig. 7f)."
40307212
sparser
"Thus, we hypothesize that USP13-STAT1 axis protects against cardiac hypertrophy through upregulating Nppb transcription and BNP expression."
40593642
reach
"This finding indicated that MBTPS1 could competitively bind to STAT1, thereby interfering with the interaction between USP13 and STAT1."
40307212
sparser
"Our study illustrated a beneficial effect of USP13 on hypertrophic cardiomyopathy and identified a cardiomyocyte-specific USP13-STAT1 axis in regulating cardiac hypertrophy."
40593642
sparser
"These results might elucidate our observation that the USP13-STAT1 axis modulates the activity of complex I in the mitochondrial respiration chain."
40593642
sparser
"USP13 directly binds STAT1 and maintains the stability of STAT1 in cardiomyocytes."
40593642
sparser
"Together, these results reveal that the USP13-STAT1 axis protects against cardiac hypertrophy by promoting STAT1 binding to the Nppb gene promoter and upregulating Nppb transcription and BNP expression (Fig.  xref )."
40593642
sparser
"Here, we demonstrate a cardiomyocyte-specific USP13-STAT1 axis in cardiac hypertrophy that effectively circumvents the potential systemic side effects associated with targeting STAT1 alone."
40593642
sparser
"To further characterize the detailed mechanism by which the USP13-STAT1 axis regulates mitochondrial function, we performed transcriptomic analysis of heart tissues from Ang II-challenged USP13cKO mice and USP13 f/f mice."
40593642
sparser
"The exogenous interaction between USP13 and STAT1 was examined in NIH/3T3 co-transfecting Flag-USP13 and STAT1 plasmids (Fig.  xref )."
40593642