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Liraglutide inhibits NLRP3. 8 / 8
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"In another mouse model of obesity, liraglutide reduced LPS-induced ALI by downregulating NLRP3 inflammasome and IL-1β [32]."
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"Moreover, the NLRP3 positive cells in the livers were also decreased by liraglutide treatment."
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"According to in vitro experiments, Liraglutide promoted M2 polarisation, activated Nrf2 and inhibited NLRP3 activation in LPS-induced microglial cells, but GLP-1R or Nrf2 knockdown reversed these effects of Liraglutide on LPS-induced microglial cells."
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"Our results found that liraglutide could reduce the NLRP3 inflammasome induced by HFD and decrease the IL-1beta secretion or caspase-1 and asc production in liver."
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"We examined whether liraglutide reduced the NLRP3 inflammasome and relieved NAFLD.In the future, we will investigate the mechanism by which liraglutide inhibits the NLRP3 inflammasome."
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"These results show that liraglutide attenuated the mitochondrial dysfunction and suppressed NLRP3 inflammasome activation in KCs.In the present study, we showed that liraglutide reduced lipid accumula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Liraglutide treatment reduces lipid accumulation, inhibits NLRP3 inflammasome and pyroptosis activation, attenuates mitochondrial dysfunction and ROS generation, and augments mitophagy in hepatocytes [175]."
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"This may have been mediated by the inhibition of NLRP3 inflammasome activation.Next, we investigated whether liraglutide could inhibit palmitic acid (PA) induced NLRP3 inflammasome activation in Kupff[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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