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Liraglutide inhibits NLRP3. 27 / 27
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"Chen et al. [ 122 ] found that liraglutide attenuated activation of NLRP3 in PVAT."
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"“PINK/PARKIN” is referred to as a canonical mitophagy pathway.55 Evidence shows that Pink and Parkin protein levels are lowered in MASLD animal models, along with apoptosis, mitophagy blockade, and altered mitochondrial architecture.565758 Liraglutide has a solid track record of its protective effects against MASLD.5960 Yu et al found that liraglutide inhibited the production of ROS, exerted anti-inflammatory effects, reduced lipid accumulation, and inhibited the activation of NLRP3 inflammasome and cell pyroptosis by activating PINK expression, suggesting that liraglutide ameliorates MASLD by enhancing mitophagy."
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"Liraglutide reduced the expression of a marker of pyroptosis (NOD)-Like Receptor with a Pyrin domain 3 (NLRP3) in the myocardium."
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"Liraglutide downregulated NLRP3, IL-1β, IL-6, and TNF, suggesting a role for the GLP-1–NLRP3 pathway in regulating intraocular inflammation and CNV formation."
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"The inhibition of mitophagy by 3-methyladenine (3-MA)/PINK1-directed siRNA dampened liraglutide suppression of NLRP3 inflammasome and pyroptosis activation, suggesting that liraglutide improved NASH by suppressing NLRP3 inflammasome and pyroptosis activation through promoting mitophagy [73]."
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"In a murine MASH model, Liraglutide reduced lipid accumulation, inhibited NLRP3 inflammasome and pyroptotic activation, and attenuated mitochondrial dysfunction and reactive oxygen species (ROS) generation."
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"In another study, it has been shown that liraglutide, a GLP-1 agonist, prevents the activation of NLRP3 inflammasome dependent pyroptosis in cardiomyoblast cells ( Chen et al., 2018 )."
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"Moreover, the NLRP3 positive cells in the livers were also decreased by liraglutide treatment."
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"This may have been mediated by the inhibition of NLRP3 inflammasome activation.Next, we investigated whether liraglutide could inhibit palmitic acid (PA) induced NLRP3 inflammasome activation in Kupff[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results show that liraglutide attenuated the mitochondrial dysfunction and suppressed NLRP3 inflammasome activation in KCs.In the present study, we showed that liraglutide reduced lipid accumula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Both in vivo and in vitro studies demonstrated that liraglutide treatment inhibited the activation of NLRP3 inflammasome in the lungs of pulmonary fibrosis model mice and in profibrotic cytokine-challenged fibroblasts."
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"In an AD mouse model, liraglutide reduces the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in the microglia, leading to the decreased production of proinflammatory cytokines and Aβ plaques [52]."
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"Our results found that liraglutide could reduce the NLRP3 inflammasome induced by HFD and decrease the IL-1beta secretion or caspase-1 and asc production in liver."
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"Our results showed that, Liraglutide significantly reduced hyperglycemia-induced oxidative stress, mRNA and protein expressions of NLRP3 inflammasome and proinflammatory cytokine levels, as well as cell membrane damage in HUVEC and HCAEC."
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"We examined whether liraglutide reduced the NLRP3 inflammasome and relieved NAFLD.In the future, we will investigate the mechanism by which liraglutide inhibits the NLRP3 inflammasome."
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"Liraglutide lowered NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in KCs and decreased mitochondrial dysfunction, leading to an important reduction in IL-1β, IL-12, and tumor necrosis factor-α (TNF-α) expression levels, while increasing the expression of IL-10 [47,48]."
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"Liraglutide treatment significantly decreased the NLRP3 positive cells count ( P <0.01, Fig. 1 D)."
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"Thus, it was speculated that liraglutide might activate Nrf2 to enter the nucleus and inhibit NLRP3 inflammasome activation.Subsequently, we verified this speculation and assessed the underlying mecha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thereby, liraglutide might inhibit the activation of NLRP3 inflammasome and promote M2 polarisation of microglia by activating Nrf2 via promoting GLP-1R expression.The effects of Nrf2 on MCAO were ass[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Liraglutide treatment significantly inhibited silica-induced upregulation of NLRP3, ASC and cleaved caspase-1 p20 in lung tissues (Fig. 1g)."
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"Liraglutide treatment reduces lipid accumulation, inhibits NLRP3 inflammasome and pyroptosis activation, attenuates mitochondrial dysfunction and ROS generation, and augments mitophagy in hepatocytes [175]."
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"In another mouse model of obesity, liraglutide reduced LPS-induced ALI by downregulating NLRP3 inflammasome and IL-1β [32]."
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"Similarly, liraglutide slows the progression of MASH by inhibiting NLRP3 inflammasome-induced hepatocyte pyroptosis by enhancing PINK1-related mitophagy [83]."
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"However, pretreatment with liraglutide decreased NLRP3 significantly compared to model group (>39% decrease, p = 0.0003)."
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"Overall, the results suggest that the inhibition of neutrophil infiltration may be another pathway through which liraglutide attenuates LPS-induced acute lung injury.In conclusion, liraglutide attenua[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thereby, Nrf2 knockdown reversed the protective effects of liraglutide by activating NLRP3 inflammasome in MCAO rats.The current work revealed that GLP-1R knockdown abrogated the protective effects of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistently, we also found the NLRP3 inflammasome was suppressed by liraglutide in H9c2 cells exposed to TNF-α and hypoxia."
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