IndraLab

Statements

PLA1A inhibits KCNH2. 2 / 2
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"For example, nonsense‐mediated mRNA decay (NMD) reduces the expression levels of many frameshift and nonsense mutations by degrading hERG mRNA (Gong et al., 2014)."
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"Thus, in homozygous Q1070X patients, most hERG mRNA transcripts are degraded by NMD before they form functional channels leading to a severe clinical phenotype [XREF_BIBR, XREF_BIBR]."
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