IndraLab

Statements

USP7 activates KAT5. 7 / 8
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"The compounds demonstrated a long-lasting inhibitory effect on murine Treg cells in vitro at 10 μM. USP7 inhibition downregulated both Foxp3 and its positive regulator Tip60."
36428632
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"We now report that both Tip60 and Foxp3 proteins are subject to ubiquitination and proteasomal degradation, whereas the actions of a deubiquitinating (DUB) enzyme, ubiquitin specific protease, Usp7 (also known as HAUSP), counteract these events and promote Tip60 and Foxp3 stability and, consequently, Treg suppressive function."
27769803
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"In addition, USP7 promotes Treg suppression by enhancing the multimerization of Tip60 and Foxp3 (153)."
31681337
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"Wang et al. documented that USP7-mediated Tip60 stabilization contributed to inflammation in acute lung injury [31]."
38129408
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"USP7 increases the stability of Tip60 by deubiquitylation and regulates the expression of early phase adipogenesis genes, including C/EBPs ."
38789534
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"TIPping the balance in adipogenesis : USP7 mediated stabilization of Tip60."
24719792
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"USP7 enhanced Tip60 protein stability, and Tip60 increased the enrichment of H3K27ac on IL-6 and IL-8 promoter region and activated NF-kappaB p65 to increase IL-6 and IL-8 expression."
32440780