IndraLab

Statements

USP7 activates KAT5. 4 / 5
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reach
"TIPping the balance in adipogenesis : USP7 mediated stabilization of Tip60."
24719792
reach
"We now report that both Tip60 and Foxp3 proteins are subject to ubiquitination and proteasomal degradation, whereas the actions of a deubiquitinating (DUB) enzyme, ubiquitin specific protease, Usp7 (also known as HAUSP), counteract these events and promote Tip60 and Foxp3 stability and, consequently, Treg suppressive function."
27769803
reach
"In addition, USP7 promotes Treg suppression by enhancing the multimerization of Tip60 and Foxp3 (153)."
31681337
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"USP7 enhanced Tip60 protein stability, and Tip60 increased the enrichment of H3K27ac on IL-6 and IL-8 promoter region and activated NF-kappaB p65 to increase IL-6 and IL-8 expression."
32440780