IndraLab

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Resveratrol inhibits TRAF6. 13 / 14
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"Resveratrol may mediate the degradation of TRAF6 and inhibit the action of epithelial–mesenchymal transition (EMT), thereby reducing the proliferation and migration of prostate cancer cells [159]."
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"In human chondrocytes, resveratrol can remarkably suppress the upregulation of TLR4 and the downstream target MyD88 and TRAF6 induced by IL-1beta [XREF_BIBR]."
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"In the present study, to evaluate the underlying mechanism of TRAF6 depletion by resveratrol, we treated the DU145 cells with different concentrations of resveratrol for 48 h and examined the nuclear [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Resveratrol may mediate the degradation of TRAF6 , thereby inhibiting the effects of EMT and decreasing the proliferation and migration of prostate cancer cells [ 62 ] ."
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"Resveratrol has been shown to mediate the degradation of TRAF6 and decrease the proliferation and migration of prostate cancer cells [141]."
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"Resveratrol disrupts colorectal cancer metastasis by activating miR-125b-5p/TRAF6 signal pathway and might improve the clinical outcome of colorectal cancer patients with low expression of miR-125b-5p."
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"Resveratrol caused a remarkable decrease of TRAF6 both in the cytoplasm and nucleus ( Fig. 3 A)."
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"Considering the notion that resveratrol affects the protein but not the mRNA level of TRAF6, we hypothesized that resveratrol causes proteasomal degradation of TRAF6."
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"This observation suggested that resveratrol mediates TRAF6 degradation via lysosome."
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"In osteoclasts, resveratrol inhibits osteoclastogenesis by suppressing the MAPK and TRAF6/TAK1 pathways while also reducing oxidative stress and inflammation through the suppression of the ROS/HIF-1α and Nox4/NF-κB pathways, respectively."
| PMC
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"In agreement with previous findings [22,26] , our data indicate that inhibition of TRAF6 by resveratrol specifically blocks p38 and JNK but not ERK MAPK pathways, suggesting that the involvement of TR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Resveratrol may mediate the degradation of TRAF6, thereby inhibiting the effects of EMT and decreasing the proliferation and migration of prostate cancer cells [XREF_BIBR]."
32905356
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"Interestingly, resveratrol decreased TRAF6 protein in both DU145 and PC3 ( Fig. 1 C)."
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