IndraLab

Statements


USP13 increases the amount of PTEN. 7 / 7
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"Results suggested that the overexpression of NF-kB p65 significantly decreased the expression levels of USP13 and PTEN, and re-introduction of USP13 rescued PTEN expression."

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"Furthermore, restoration of USP13 rescued PTEN expression, cell phenotypes and xenograft tumor growth which is altered by NF-kB activation."

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"In addition, reintroduction of USP13 partially rescued PTEN expression as well as the oncogenesis trend caused by NF-kB."

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"Our data revealed that knockdown of USP13 by short hairpin RNA (shRNA) significantly decreased PTEN protein expression in BC cells."

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"Results indicated that USP13 knockdown notably decreased PTEN protein expression and increased phosphor-AKT levels in BC cells."

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"Although each of these five DUBs could interact with endogenous PTEN (XREF_SUPPLEMENTARY), only one of them, USP13, significantly increased endogenous PTEN protein expression (XREF_SUPPLEMENTARY)."

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"Moreover, reintroduction of USP13 repressed the signaling transduction of NF-kB and largely rescued PTEN expression in NF-kB activated or miR-130b/301b overexpressed BC cells."