IndraLab

Statements


USP13 increases the amount of PTEN. 10 / 10
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"Results suggested that the overexpression of NF-kB p65 significantly decreased the expression levels of USP13 and PTEN, and re-introduction of USP13 rescued PTEN expression."

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"6 In OSCC tissues, PTEN expression is downregulated and negatively associated with activated AKT.7 10 Consistent with earlier findings, USP13 increased PTEN protein levels and decreased p-AKT levels in OSCC cells, and overexpression of PTEN partially reversed the USP13-knockdown-induced glucose uptake and lactate production in the present study.Loss of PTEN and abnormal AKT activation influences the regulation of various downstream effectors, thus contributing to tumorigenesis.11 13 GLUT1 and HK2 are important glycolysis regulators downstream of the AKT pathway.26 27 AKT activity is essential for insulin-induced GLUT1 gene expression."

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"Moreover, reintroduction of USP13 repressed the signaling transduction of NF-kB and largely rescued PTEN expression in NF-kB activated or miR-130b/301b overexpressed BC cells."

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"USP13 upregulated PTEN expression and restrained oxidative stress, apoptosis, and inflammation in OA via AKT signaling [8]."

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"Furthermore, restoration of USP13 rescued PTEN expression, cell phenotypes and xenograft tumor growth which is altered by NF-kB activation."

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"In these tumors, USP13 interacts with and deubiquitinates the tumor suppressor PTEN protein, thereby stabilizing and increasing the expression of PTEN [16–18]."

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"Results indicated that USP13 knockdown notably decreased PTEN protein expression and increased phosphor-AKT levels in BC cells."

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"Although each of these five DUBs could interact with endogenous PTEN (XREF_SUPPLEMENTARY), only one of them, USP13, significantly increased endogenous PTEN protein expression (XREF_SUPPLEMENTARY)."

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"In addition, reintroduction of USP13 partially rescued PTEN expression as well as the oncogenesis trend caused by NF-kB."

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"Our data revealed that knockdown of USP13 by short hairpin RNA (shRNA) significantly decreased PTEN protein expression in BC cells."