
IndraLab
Statements
reach
"6 In OSCC tissues, PTEN expression is downregulated and negatively associated with activated AKT.7 10 Consistent with earlier findings, USP13 increased PTEN protein levels and decreased p-AKT levels in OSCC cells, and overexpression of PTEN partially reversed the USP13-knockdown-induced glucose uptake and lactate production in the present study.Loss of PTEN and abnormal AKT activation influences the regulation of various downstream effectors, thus contributing to tumorigenesis.11 13 GLUT1 and HK2 are important glycolysis regulators downstream of the AKT pathway.26 27 AKT activity is essential for insulin-induced GLUT1 gene expression."