IndraLab

Statements

CALM binds CACNA1G. 6 / 6
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sparser
"We now report that under resting conditions, CaM constitutively associates with the C-terminus of Cav3.1, as revealed in both a heterologous expression system and rodent brain."
28800734
sparser
"Our findings thus establish that T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to αCaMKII activation."
28800734
sparser
"We tested the potential for Cav3.1 and CaM to physically associate using coimmunoprecipitation, first performed in the presence of a buffered calcium concentration of 100 nM to simulate resting conditions of intracellular calcium (see xref )."
28800734
sparser
"These findings are important in revealing a dynamic interaction between Cav3.1 and CaM that is essentially opposite to that of HVA calcium channels."
28800734
sparser
"Dynamics of Cav3.1 and CaM interactions revealed by FRET."
28800734
sparser
"The precise amino acid residues on the C-terminus responsible for the Cav3.1-CaM interaction remain to be determined."
28800734