IndraLab

Statements


| 6

sparser
"These findings are important in revealing a dynamic interaction between Cav3.1 and CaM that is essentially opposite to that of HVA calcium channels."

sparser
"The precise amino acid residues on the C-terminus responsible for the Cav3.1-CaM interaction remain to be determined."

sparser
"Our findings thus establish that T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to αCaMKII activation."

sparser
"We now report that under resting conditions, CaM constitutively associates with the C-terminus of Cav3.1, as revealed in both a heterologous expression system and rodent brain."

sparser
"We tested the potential for Cav3.1 and CaM to physically associate using coimmunoprecipitation, first performed in the presence of a buffered calcium concentration of 100 nM to simulate resting conditions of intracellular calcium (see xref )."

sparser
"Dynamics of Cav3.1 and CaM interactions revealed by FRET."