IndraLab
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"As VHL targets hypoxia‐inducible transcription factor (HIF‐α) for degradation, VHL inactivation and HIF‐α activation were associated with the oncogenic driver. xref USP15 is a component of the COP9 signalosome complex (CSN), which is associated with VHL. xref , xref Therefore the interaction between USP15 and VHL requires intensive study in the future."