IndraLab

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"As VHL targets hypoxia‐inducible transcription factor (HIF‐α) for degradation, VHL inactivation and HIF‐α activation were associated with the oncogenic driver. xref USP15 is a component of the COP9 signalosome complex (CSN), which is associated with VHL. xref , xref Therefore the interaction between USP15 and VHL requires intensive study in the future."

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"25 , 26 Therefore the interaction between USP15 and VHL requires intensive study in the future.It has been well established that dysregulated transcriptional programs are closely related to the occurrence and development of various neoplasias, including ccRCC."