IndraLab

Statements

Glucose inhibits CASP1. 4 / 5
| 4
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"Deciphering the underlying mechanism of PAOS-improving diabetes, the results revealed that PAOS downregulated the blood glucose level by activating PI3K/AKT/mTOR and Keap/Nrf2/HO-1 pathways, meanwhile inhibiting TLR4/MAPK/NF-κB, Beclin1/LC3, and NLRP3/caspase1 pathways in vivo."
36364880
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"Similar to the effects of 2DG, glucose deprivation inhibited caspase-1 activation and secretions of IL-1beta and IL-18 in wild-type BMDMs in response to LPS and ATP, while TNF secretion was unchanged."
26119735
reach
"Glucose deprivation and genetic or pharmacologic inhibition of mTOR signaling or HK1 in macrophages all blunted glycolysis and prevented NLRP3 inflammasome mediated caspase-1 activation."
| PMC
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"Similar to the effects of 2DG, glucose deprivation inhibited caspase-1 activation and secretion of IL-1beta and IL-18 in wild type BMDM in response to LPS and ATP, while TNF secretion was unchanged (XREF_FIG)."
26119735