IndraLab

Statements

Glucose inhibits CASP1. 8 / 9
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"The emerging study also reported that knockdown of the CACR in cardiomyocytes opposed HG-stimulated caspase-1 activation.173 Intriguingly, miR-214-3p knockdown could partly abolish the favorable outcomes of CACR silencing on pyroptosis in cardiomyocytes."
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"Glucose deprivation and genetic or pharmacologic inhibition of mTOR signaling or HK1 in macrophages all blunted glycolysis and prevented NLRP3 inflammasome mediated caspase-1 activation."
| PMC
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"Deciphering the underlying mechanism of PAOS-improving diabetes, the results revealed that PAOS downregulated the blood glucose level by activating PI3K/AKT/mTOR and Keap/Nrf2/HO-1 pathways, meanwhile inhibiting TLR4/MAPK/NF-kappaB, Beclin1/LC3, and NLRP3/caspase1 pathways in vivo."
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"Furthermore, puerarin increased SIRT1 expression in DN mice and HG-treated MPC-5 cells, inhibited the activation of the NLRP3/Caspase-1 pathway, reduced podocyte pyroptosis, and alleviated renal inflammatory damage."
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"Similar to the effects of 2DG, glucose deprivation inhibited caspase-1 activation and secretion of IL-1beta and IL-18 in wild type BMDM in response to LPS and ATP, while TNF secretion was unchanged (XREF_FIG)."
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"As depicted in Figure 7, compared to the HG group, knockdown of lncMEG3 shRNA and stimulation with HG significantly decreased the expressions of pyroptosis-related proteins including NLRP3, ASC, Caspase-1, Caspase-1 cut, IL-1β, and IL-18."
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"PB2 significantly suppressed pyroptosis in endothelial cells exposed to high glucose by inhibiting the caspase-1/GSDMD signaling pathway."
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"28 Overwhelming evidence confirms that exposure to high glucose inhibits Nrf2/Keap1 signalling, leading to oxidative stress induction, assembly of Nlrp3, activation of Caspase1, and subsequent initiation of pyroptosis."
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