IndraLab

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"In addition, c-fos induction in response to acute restraint stress was down-regulated by chronic, but not acute, administration of tranylcypromine or imipramine, two drugs that nonselectively increase synaptic levels of norepinephrine and serotonin by inhibition of monoamine oxidase or neurotransmitter reuptake, respectively."

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"However, the dual NET-SERT inhibitor imipramine, which is also less effective at promoting sleep than other TCAs, decreases c-Fos in the LC [XREF_BIBR]."

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"The imipramine increased c-Fos immunoreactivity was suppressed in the mPFC of rats repeatedly treated with ACTH."

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"Imipramine decreased c-Fos in the basolateral amygdala and hippocampus (CA1 and CA3), but increased c-Fos in the central amygdala."

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"To elucidate the mechanisms by which imipramine attenuates MetS-exacerbated periodontitis, we showed that imipramine inhibited the upregulation of pro-inflammatory cytokines and transcription factor c-FOS as well as ceramide production by LPS plus PA in macrophages."