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USP8 increases the amount of IFNB. 4 / 4
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"To investigate the effect of USP6, we knocked down USP6 and USP8 in THP-1 cells and observed that USP6 knockdown slightly enhanced IFNB expression, while USP8 knockdown significantly decreased IFNB ex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Intriguingly, we found that DUB-IN-2, a specific inhibitor of USP8, also strongly inhibited the induction of Ifnb and Il6 expression by HSV60 transfection ( Figure S1 F)."
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"We also reconstituted USP8 in Usp8 KO RAW264.7 cells and observed that the reintroduction of USP8 rescued Ifnb expression upon HSV60 transfection ( Figure S2 B), suggesting that the decreased type I i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with the results from the knockdown assay, we observed that the stimulation of USP8-deficient RAW264.7 cells with HSV60 decreased the expression of Ifnb , two ISGs, Ccl5 , and Isg15 ( Figur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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