IndraLab

Statements

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"Although PINK1/Parkin-mediated mitophagy has been well studied, no effective drug targeting this pathway has been employed for the treatment of neurodegenerative diseases.As a negative feedback mechan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP15, USP30 and USP35 inhibit mitophagy by removing the ubiquitin signal from Parkin targets [46–48]."
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"Moreover, USP15 inhibition can promote mitophagy and alleviate mitochondrial defects in a Parkinson’s disease model ."
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"Interestingly, RNAi-mediated knockdown of USP15 in these fibroblasts strongly enhanced mitophagy, so that mitophagy already became demonstrable after 24 h exposure to CCCP or valinomycin (Fig. 2H–K)."
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"What could be the mechanism for the inhibitory effect of USP15 on Parkin-mediated mitophagy?"
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"The C269A mutation abolished the inhibitory effect of USP15 on Parkin-mediated mitophagy, indicating that this effect of USP15 required its deubiquitinating activity (Fig. 1; Supplementary Data)."
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"Furthermore, depleting endogenous USP15 enhanced mitophagy in HeLa cells, in a human dopaminergic neuronal cell line and in primary fibroblasts from human patients ."
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"Knockdown of USP15 enhances mitophagy."
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