IndraLab

Statements

USP19 binds HDAC1/2. 4 / 6
| 4
reach
"In addition, we also detected the association between HDAC1/2 and USP19 upon DNA damage both in exogenous and endogenous station."
27517492
reach
"Based on this observation, and considering that USP19 interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair and chromosomal stability (Wu et al., 2017) and that both ccRCC and HGSC are characterized by high genomic instability, it is plausible that USP19-mediated deubiquitination of key regulators associated with DSB repair or genome instability might be responsible for the worse prognosis observed in ccRCC and HGSC patients with low USP19 levels (Kang et al., 2021)."
35646888
reach
"To further confirm the interaction between USP19 and HDAC1/2, we transfected Flag tagged HDAC1 or HDAC2 together with Myc tagged USP19 into HEK293T cells and co-immunoprecipitaion experiment was performed."
27517492
reach
"USP19 physically interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair, chromosomal stability, and tumorigenesis, and USP19 expression is low or depleted in several types of tumors [32]."
| PMC