IndraLab

Statements

USP18 activates IFNAR2. 2 / 3
| 2
reach
"Even though type III IFN signaling requires JAK1, it is not affected by USP18 as USP18 specifically targets and binds IFNAR2 and not IFNLR."
33362795
reach
"It is thus tempting to speculate that while the regulation of IFNAR2 signaling and ISG15 conjugation by USP18 are enzyme-independent and enzyme-dependent processes, respectively, they could still be coordinated by the same mechanism which involves the TAIL motif."
38853827