IndraLab

Statements

USP8 inhibits HYCC1. 6 / 6
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"The ubiquitin specific peptidase 8 (USP8), which was found to favor HCC progression, inhibited the O-GlcNAcylation of SLC7A11 to stabilize its expression, thus facilitating the ferroptosis of HCC [26, 27]."
39538215
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"Taken together, pharmacological inhibition or knockout of USP8 may suppress glutathione biosynthesis by inhibiting HCC cells absorbing cystine from the extracellular environment and conferring ferroptosis.2.3 USP8 Stabilizes OGT Through the Deubiquitylation Activity."
37867237
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"In the present study, we observed that inhibition of USP8 promoted ferroptosis of HCC cells."
37311739
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"Targeting USP8 inhibits the proliferation of HCC and induces cell ferroptosis."
37867237
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"As shown in Fig. 6, inhibition of USP8 by DUB-IN-3 caused a dose-dependent suppression on the proliferation, invasion, stem-like properties and promoted ferroptosis of HCC cells (Fig. 6A–J)."
37311739
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"High expression of USP8 promoted the progression and inhibited ferroptosis of HCC."
37311739