IndraLab

Statements

OTUB1 activates Ubiquitin. 3 / 4
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"For this, heterotypic Ub chains were assembled from 25 mg WT Ub, and the reaction was subsequently treated with OTUB1, which cleaved all Lys48-linkages within the polymers."
23563141
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"OTUB1 has previously been reported to inhibit ubiquitylation of target proteins by interacting with and inhibiting E2 ubiquitin conjugating enzymes XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
24071738
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"Immunoblot analysis revealed that ubiquitin chains were completely degraded by AMSH but neither by OTUB1 nor the GST control, further supporting our finding that TRIAD3 synthesises K63 linked ubiquitin chains in vitro, full length TRIAD3 protein as well as the TRIAD3-RBR 845 fragment."
30886743