IndraLab

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KCNQ1 binds Yotiao. 7 / 7
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"These results indicate that the impaired membrane trafficking of the KCNQ1 (A590T) subunit was rescued by the co-expression with KCNQ1 (WT) subunit.The helix D region of KCNQ1 subunit contains G589, t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
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"The disruption of the cAMP dependent I Ks regulation by mutations in helix D indicates that Yotiao interacts with KCNQ1 through this domain [13]."
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"Finally, AC9 association with the KCNQ1 and Yotiao complex sensitized PKA phosphorylation of KCNQ1 to beta-adrenergic stimulation."
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"A subset of KCNQ1 or Yotiao mutations reduce binding of Yotiao and KCNQ1, disrupting sympathetic regulation of I KS."
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"Therefore AC9 is the only AC isoform that interacts with the Yotiao and KCNQ1 complex in the heart."
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"The molecular nature of the binding between Yotiao and KCNQ1 involves the distal C-terminus of the channel and both the C and N termini of Yotiao."
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