IndraLab

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Ubiquitin activates UCHL3. 2 / 2
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"This result was similar to that conducted by UCHL3, which produced more free coumarin over time (Fig. 2g) and was previously demonstrated to be activated by distal Ub ."
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"Regulating biological functions, UCHL3 promoted GSC proliferation, tumorigenesis, self-renewal, and radioresistance in a POLD4-dependent manner.The degradation of POLD4 by ubiquitin ligases in response to DNA damage and during cell cycle progression plays a less prominent role in normal cells [43], while with increasing insights into the complex mechanisms of DNA damage repair, POLD4 is projected to play an increasingly important role."
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