IndraLab

Statements

OTUB1 increases the amount of SLC7A11. 4 / 4
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"OTUB1 inactivation promotes ferroptosis in human cancer cells primarily by down-regulating SLC7A11 levels."
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"Together, these data suggest that OTUB1 inactivation promotes ferroptosis in human cancer cells primarily by down-regulating SLC7A11 levels."
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"In particular, our results show that (i) OTUB1 is a bona fide binding partner of SLC7A11 both in vitro and in vivo; (ii) OTUB1 acts as a major regulator for SLC7A11 activity in human cancer cells; (iii) OTUB1 inactivation promotes ferroptosis in human cancer cells primarily by down-regulating SLC7A11 levels; (iv) OTUB1 is overexpressed in human cancers and the OTUB1-SLC7A11 interaction is critical for tumor growth; (v) The OTUB1-SLC7A11 interaction is tightly regulated by CD44 in human cancer cells."
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"OTUB1 directly interacted with and stabilized SLC7A11; conversely, OTUB1 knockdown diminished SLC7A11 levels in cancer cells."
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