IndraLab

Statements

STK4 binds USP46. 9 / 9
2 | 2 5
sparser
"In conclusion, we found that USP46 interacts with MST1 and decreases the polyubiquitination of MST1, stabilizing MST1 and leading to the inactivation of YAP1 in HCC."
34029571
sparser
"To test this hypothesis, we first validated the specificities of USP46 and MST1 interactions in HCC cells."
34029571
biogrid
No evidence text available
34029571
sparser
"As expected, co-IP assays confirmed the interaction between USP46 and MST1 using endogenous USP46 and MST1 antibodies in Huh-7 and Hep3B cells ( Fig. 6 A)."
34029571
biogrid
No evidence text available
34029571
sparser
"In addition, we revealed that USP46 interacts with the Hippo pathway core component MST1."
34029571
reach
"To test this hypothesis, we first validated the specificities of USP46 and MST1 interactions in HCC cells."
34029571
reach
"As expected, co-IP assays confirmed the interaction between USP46 and MST1 using endogenous USP46 and MST1 antibodies in Huh-7 and Hep3B cells ( Fig. 6 A)."
34029571
sparser
"Furthermore, USP46 directly binds to the MST1 protein and lowers its ubiquitination, stabilizing it."
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