IndraLab

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"The results from the in vitro and in vivo experiments indicated that PQ significantly promoted the process of IkappaBalpha degradation to p-IkappaBalpha, leading to an increase in the transfer of NF-kappaB p65 to the nucleus."

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"This phenomenon indicated that PQ induced degradation of IkappaB-alpha, and thus NF-kappaB p65 was released and transferred to the nucleus, resulting in activation of the downstream proinflammatory gene."