IndraLab

Statements

CACNA1C binds SNP. 7 / 7
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"Taken together, the current findings provide evidence that the CACNA1C SNP rs1006737 is associated with increased amygdala activity across different diagnostic groups."
23437284
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"These results support the notion that variations at the rs1006737 SNP in the CACNA1C gene are associated with Ca V 1.2 channel function in human excitatory neuron-like cells."
25403839
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"Even though it is not consistently observed xref , xref , the majority of evidence suggests that the non-coding risk SNP rs1006737 is associated with enhanced CACNA1C expression and a gain of Ca V 1.2 function xref , xref , xref , suggesting deregulated Ca 2+ signaling in the affected population and a significantly increased probability of psychiatric diseases xref ."
29760952
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"Although we observed nominal association of the bipolar disorder–associated CACNA1C SNP rs1006737 with global gray matter volume in 281 healthy individuals as described earlier in a sample of 77 sub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20638048
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"Notably, we recapitulated the previously identified interaction between CACNA1C and a schizophrenia-associated SNP associated with decreased enhancer activity xref ."
27760116
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"In the exploratory analyses, we found genotype by diagnosis interactions between SNP rs4765913 of the CACNA1C gene and the sensory gating phenotype and between SNP rs13000464 of the GLS gene and P300 amplitude."
24339136
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"Elevated cytosolic calcium levels, which may be associated with the CACNA1C risk SNP rs 1006737, represent a major upstream pathway that impairs mitochondrial function in BD xref ."
29760952