IndraLab

Statements

Hydroxide inhibits NFKB1. 3 / 3
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"1,25 (OH) 2 D 3 can also directly suppress RelB transcription [XREF_BIBR], as well as suppress the increase in p50 and its precursor, p105, and c-rel proteins [XREF_BIBR]."
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"Thus, TNF/NFkB activity is markedly impaired by 1,25(OH) 2 D at multiple levels."
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"More recently, Bruns et al. [XREF_BIBR] reported that tumor derived, miR155 containing exosomes can promote production of M-MDSC from monocytes and that 1,25 (OH) 2 D suppresses NFkB mediated production of miR155 containing exosomes by chronic lymphocytic leukemia cells."
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