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OTUB2 increases the amount of CALML3. 2 / 2
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"In contrast, Chang et al. [56] discovered that OTUB2 is missing in ESCC tissues, while OTUB2 can deubiquitinate STAT1 and phosphorylate it, thereby activating CALML3 transcription and phospholipid acetylserine synthesis to exert tumor suppressive effects."
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"Moreover, OTUB2 promotes the interaction between STAT1 and JAKs, increases STAT1 phosphorylation at Tyr701, and augments the transcriptional activity of STAT1 to activate CALML3 expression."
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