IndraLab

Statements

CTTN binds KCNA2. 13 / 16
4 1 | 8
biogrid
No evidence text available
17959782
sparser
"We use FRET to demonstrate that Kv1.2 and cortactin interact in vivo."
17959782
sparser
"These results demonstrate a dynamic, phosphorylation-dependent interaction between Kv1.2 and the actin cytoskeleton-binding protein cortactin and suggest a role for that interaction in the regulation of Kv1.2 ionic current."
12151401
sparser
"We show that M1 receptor activation also reduces the interaction of cortactin with Kv1.2 and that mutant Kv1.2 channels deficient for cortactin binding exhibit strongly attenuated ionic current."
12151401
sparser
"For example, the association of Kv1.2 with the σ-1 receptor has been proposed to promote forward trafficking of the channel as well as to modulate its gating ( xref ; xref ), whereas the association of Kv1.2 with cortactin, an actin binding protein, is thought to increase endocytosis of the channel ( xref )."
32579683
sparser
"It was well established that cortactin played a critical role in cell migration through its interaction with small GTPases and F‐actin (Kowalski et al., xref ; Van Rossum et al., xref ; MacGrath and Koleske, xref ), and that cortactin directly binds to Kv1.2 and modulates channel functions (Williams et al., xref )."
26580832
sparser
"These data also suggest that the Kv1.2 ‐cortactin interaction is greater in Kv1.2‐C COS‐7 cells than in WT COS‐7 cells, possibly due to the fact that Kv1.2‐C COS‐7 cells essentially expressed more Kv1.2 channel proteins which subsequently bound higher quantity of cortactin."
26580832
sparser
"Mutagenesis studies revealed that phosphorylation of Kv1.2 Y415 and Y417 causes disruption of Kv1.2 interaction with the cytoskeletal protein cortactin, and loss of interaction with cortactin diminishes the total Kv1.2 current in heterologous expression systems [ xref ]."
20600597
biogrid
No evidence text available
12151401
sparser
"We report that the potassium channel Kv1.2 associates with the actin-binding protein cortactin and that the binding is modulated by tyrosine phosphorylation."
12151401
hprd
No evidence text available
12151401
biogrid
No evidence text available
12151401
biogrid
No evidence text available
17959782