IndraLab

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USP13 activates ACLY. 6 / 9
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"USP13 led to the upregulation of ACLY and oxoglutarate dehydrogenase (OGDH), which is one of the subunit of α-ketoglutarate dehydrogenase complex, an enzymatic complex involved in glutaminolysis."
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"USP13 primarily deubiquitinates and therefore upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two crucial enzymes that control glutaminolysis and fatty acid synthesis and also mitochondrial respiration."
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"USP13 upregulates ACLY and OGDH, two key regulators that drive glutaminolysis, ATP generation and lipid synthesis in cancer metabolism."
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"USP13-KD also significantly decreased ACLY activity, while USP13 overexpression enhanced ACLY activity in the ACLY activity assay (XREF_SUPPLEMENTARY)."
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"In ovarian cancer, USP13 upregulates ATP citrate lyase (ACLY) via deubiquitination, enhancing fatty acid synthesis and accelerating tumour growth [16]."
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"Next, we examined whether USP13 augments the stability of ACLY and OGDH."
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