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USP6 binds RALBP1. 15 / 15
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"Furthermore, IP assays showed that the binding of USP6 to RALBP1 decreased upon ALKBH5 overexpression (Fig. xref K)."
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"This inhibition prevents the formation of the RALBP1-USP6 complex, leading to increased degradation of RALBP1 and reduced activation of the downstream PI3K/Akt/mTOR pathway."
39815301
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"Collectively, our results indicated that WRAP53 promoted the binding of USP6 to RALBP1, thereby upregulating RALBP1 expression."
39815301
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"WRAP53 exerts a pro-cancer effect in GC, by acting as a scaffold that facilitates the physical interaction between USP6 and RALBP1 proteins, resulting in RALBP1 deubiquitylation and upregulation."
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"Co-IP assays using HA-tag RALBP1 and HA-tag USP6 overexpression vectors confirmed the endogenous RALBP1-USP6 protein complex (Fig. xref I ,  J)."
39815301
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"We speculated that WRAP53 facilitates the binding of USP6 to RALBP1, allowing USP6 to deubiquitinate RALBP1 and protect it from degradation."
39815301
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"The lower level of WRAP53 disrupts the interaction between USP6 and RALBP1 protein, promoting RALBP1 degradation and thereby suppressing the PI3K/Akt/mTOR signaling cascade, ultimately attenuating the progression of GC."
39815301
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"We speculated that WRAP53 facilitates the binding of USP6 to RALBP1, allowing USP6 to deubiquitinate RALBP1 and protect it from degradation."
39815301
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"Furthermore, IP assays showed that the binding of USP6 to RALBP1 decreased upon ALKBH5 overexpression (Fig. 6K)."
39815301
sparser
"In this study, we show that the decrease in WRAP53 expression diminishes its function as a scaffold for the interaction between RALBP1 and USP6, resulting in increased degradation of RALBP1 and subsequently suppressing gastric cancer growth and metastasis."
39815301
reach
"Collectively, our results indicated that WRAP53 promoted the binding of USP6 to RALBP1, thereby upregulating RALBP1 expression."
39815301
reach
"This inhibition prevents the formation of the RALBP1-USP6 complex, leading to increased degradation of RALBP1 and reduced activation of the downstream PI3K/Akt/mTOR pathway."
39815301
reach
"In this study, we show that the decrease in WRAP53 expression diminishes its function as a scaffold for the interaction between RALBP1 and USP6, resulting in increased degradation of RALBP1 and subsequently suppressing gastric cancer growth and metastasis."
39815301
reach
"WRAP53 upregulates RALBP1 by promoting USP6 and RALBP1 protein interaction."
39815301
sparser
"WRAP53 upregulates RALBP1 by promoting USP6 and RALBP1 protein interaction."
39815301