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Peptide inhibits STING1. 10 / 10
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"In comparison to mammalian counterparts in which fusion peptide of HA2 (HA2-FP) blocks STING (an adapter protein for downstream signaling)( Holm et al., 2016 ), no such studies regarding the role of A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly to the HCMV UL94 protein, the fusion peptide of the IAV HA protein blocks STING dimerization but only when the protein is activated in a non-canonical way by membrane fusion and not by 2′3′-cGAMP [77]."
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"The 162–172 fragment is also targeted by a viral protein fusion peptide (FP) of the influenza A virus (IAV) to antagonize STING dimerization for immune evasion."
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"A peptide inhibitor of STING has also recently been described that acts in a STIM1-dependent manner to block STING trafficking from the ER to the Golgi."
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"This peptide, ISD017, inhibits known STING downstream activities and has no overt toxic effects on cells."
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"Research indicates that the influenza virus A can evade the innate immune surveillance of cells because the fusion peptide (FP) of its hemagglutinin protein can interact with STING, thereby inhibiting[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Influenza A virus interacts with STING through its conserved hemagglutinin fusion peptide (FP) to inhibits STING activation in response to membrane fusion [58]."
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"Fusion peptide inhibits STING activation triggered by membrane fusion, a function of STING previously noted (Holm et al. 2012)."
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"Here we report a peptide , ISD017 , which effectively blocks STING signaling by specifically inhibiting STING trafficking out of the ER through a mechanism dependent on the STING ER retention factor STIM1 ."
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"Administration of the ISD017 peptide, which blocks STING trafficking from the ER, improved glomerular pathology scores and reduced IgG deposition in the kidney, which suggested that STING-targeted therapeutics might be useful in lupus nephritis ."
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